7114668

Tocris Bioscience™ SR 10067

Selective Rev-Erbα/β agonist; anxiolytic

Manufacturer: Fischer Scientific

CAS Number: 1380548-02-6

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Chemical Name or Material

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

Assay Percent Range

>98%

Formula Weight

Observed MW: 465.58

CAS

1380548-02-6

Molecular Formula

C31H31NO3

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Description

  • Selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively)
  • Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM
  • Increases wakefulness, reduces REM and slow wave sleep in vivo
  • Also reduces anxiety-like behavior in marble-burying assay
  • Cell permeable and brain penetrant.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

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Selective Rev-Erbα/β agonist; anxio...


Chemical Name or Material:
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

Assay Percent Range:
>98%

Formula Weight:
Observed MW: 465.58

CAS:
1380548-02-6

Molecular Formula:
C31H31NO3

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Molecular Formula:
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