7116034
Clofarabine
Deoxycytidine kinase (dCK) substrate
Manufacturer: Fischer Scientific
CAS Number: 123318-82-1
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Chemical Name or Material
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Assay Percent Range
>99%
Formula Weight
Observed MW: 303.68
CAS
123318-82-1
Molecular Formula
C10H11ClFN5O3
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Description
- Deoxycytidine kinase (dCK) substrate
- Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM)
- Induces apoptosis by directly altering mitochondrial transmembrane potential
- Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
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Chemical Name or Material: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Assay Percent Range: >99%
Formula Weight: Observed MW: 303.68
CAS: 123318-82-1
Molecular Formula: C10H11ClFN5O3
Chemical Name or Material:
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Assay Percent Range:
>99%
Formula Weight:
Observed MW: 303.68
CAS:
123318-82-1
Molecular Formula:
C10H11ClFN5O3
Chemical Name or Material: N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
Assay Percent Range: >99%
Formula Weight: Observed MW: 285.39
CAS: 73029-73-9
Molecular Formula: C16H23N5
Chemical Name or Material:
N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
Assay Percent Range:
>99%
Formula Weight:
Observed MW: 285.39
CAS:
73029-73-9
Molecular Formula:
C16H23N5
Chemical Name or Material: 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Assay Percent Range: >99%
Formula Weight: Observed MW: 320.34
CAS: 113906-27-7
Molecular Formula: C19H16N2O3
Chemical Name or Material:
2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Assay Percent Range:
>99%
Formula Weight:
Observed MW: 320.34
CAS:
113906-27-7
Molecular Formula:
C19H16N2O3
Chemical Name or Material: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Assay Percent Range: >99%
Formula Weight: Observed MW: 371.88
CAS: 1203680-76-5
Molecular Formula: C20H18ClNO2S
Chemical Name or Material:
3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Assay Percent Range:
>99%
Formula Weight:
Observed MW: 371.88
CAS:
1203680-76-5
Molecular Formula:
C20H18ClNO2S