7161604
Tocris Bioscience™ PSEM 308 hydrochloride
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Manufacturer: Fischer Scientific
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Chemical Name or Material
5-Methyl-5,8,9,10,11 A,12-hexahydro-4 H-8,11-ethanopyrido[3 ',2 ':3,4 ]diazepino[6,7,1-hi]indole hydrochloride
Molecular Formula
C17H21N3.HCl
Purity
98%
Target
Pharmacologically Selective Effector Molecules/PSEM
Formula Weight
303.83
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Description
- PSAM (pharmacologically selective actuator module) agonist
- Activates PSAML141F-GlyR chimeric ion channels
- Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels
- Recommended concentration for use in mice is 5 mg/kg or lower
- Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C