7161664
Tocris Bioscience™ PSEM 89S
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Manufacturer: Fischer Scientific
CAS Number: 1336913-03-1
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Chemical Name or Material
N-(3 S)-1-Azabicyclo[2.2.2 ]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Target
Pharmacologically Selective Effector Molecules/PSEM
Formula Weight
404.38
CAS
1336913-03-1
Molecular Formula
C16H22N2O3.CF3CO2H
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ PSEM 89S | Fischer Scientific | ₹ 79,271.34 | |
| | Tocris Bioscience™ PSEM 89S | Fischer Scientific | ₹ 20,619.96 | |
 | Medchemexpress LLC HY-112217A 5mg Medchemexpress, PSEM 89S (TFA) CAS:1336913-03-1 Purity:>98% | Medchemexpress LLC | ₹ 10,780.56 | |
 | 1336913-03-1 | N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamidetrifluoroacetate | A2B Chem | ₹ 1,796.76 - ₹ 46,116.84 |
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Description
- PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively)
- Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro
- Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo , leading to suppression of feeding
- Brain penetrant
- Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: N-(3 S)-1-Azabicyclo[2.2.2 ]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Target: Pharmacologically Selective Effector Molecules/PSEM
Formula Weight: 404.38
CAS: 1336913-03-1
Molecular Formula: C16H22N2O3.CF3CO2H
Purity: 98%
Chemical Name or Material:
N-(3 S)-1-Azabicyclo[2.2.2 ]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Target:
Pharmacologically Selective Effector Molecules/PSEM
Formula Weight:
404.38
CAS:
1336913-03-1
Molecular Formula:
C16H22N2O3.CF3CO2H
Purity:
98%
Chemical Name or Material: 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride
Target: __
Formula Weight: 416.99
CAS: 195055-66-4
Molecular Formula: C22H32N6.HCl
Purity: 98%
Chemical Name or Material:
3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride
Target:
__
Formula Weight:
416.99
CAS:
195055-66-4
Molecular Formula:
C22H32N6.HCl
Purity:
98%
Chemical Name or Material: (2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Target: __
Formula Weight: 362.4
CAS: 1357389-11-7
Molecular Formula: C21H19FN4O
Purity: 98%
Chemical Name or Material:
(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Target:
__
Formula Weight:
362.4
CAS:
1357389-11-7
Molecular Formula:
C21H19FN4O
Purity:
98%
Chemical Name or Material: 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Target: __
Formula Weight: 495.53
CAS: 160970-54-7
Molecular Formula: C25H32F3N3O4
Purity: 98%
Chemical Name or Material:
2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Target:
__
Formula Weight:
495.53
CAS:
160970-54-7
Molecular Formula:
C25H32F3N3O4
Purity:
98%