7166786
Tocris™ Pyridone 6
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
Manufacturer: Fischer Scientific
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Synonym
JAK inhibitor I
Formula Weight
309.34
Purity
98%
Molecular Formula
C18H16FN3O
Product Type
Inhibitor
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Description
- Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively)
- Inhibits other kinases tested at 130 nM to >10 μM
- Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation
- Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells
- When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs
- Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells
- Cell-permeable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Synonym: JAK inhibitor I
Formula Weight: 309.34
Purity: 98%
Molecular Formula: C18H16FN3O
Product Type: Inhibitor
Synonym:
JAK inhibitor I
Formula Weight:
309.34
Purity:
98%
Molecular Formula:
C18H16FN3O
Product Type:
Inhibitor
Synonym: __
Formula Weight: 440.88
Purity: 98%
Molecular Formula: C22H21ClN4O4
Product Type: Agonist
Synonym:
__
Formula Weight:
440.88
Purity:
98%
Molecular Formula:
C22H21ClN4O4
Product Type:
Agonist
Synonym: JC121
Formula Weight: 368.84
Purity: 98%
Molecular Formula: C16H17ClN2O4S
Product Type: Inhibitor
Synonym:
JC121
Formula Weight:
368.84
Purity:
98%
Molecular Formula:
C16H17ClN2O4S
Product Type:
Inhibitor
Synonym: Ramelteon
Formula Weight: 259.34
Purity: 98%
Molecular Formula: C16H21NO2
Product Type: Agonist
Synonym:
Ramelteon
Formula Weight:
259.34
Purity:
98%
Molecular Formula:
C16H21NO2
Product Type:
Agonist