ML 67-33 is a K2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes)
Increases channel currents by activating core gating apparatus of channels.