7166827
Tocris™ DPTIP
Potent and selective N-SMase2 inhibitor; brain penetrant
Manufacturer: Fischer Scientific
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Molecular Formula
C21H18N2O3S
Formula Weight
378.45
Product Type
Inhibitor
Purity
98%
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Description
- DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM)
- Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase
- Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo
- Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain
- Metabolically stable and brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Molecular Formula: C21H18N2O3S
Formula Weight: 378.45
Product Type: Inhibitor
Purity: 98%
Molecular Formula:
C21H18N2O3S
Formula Weight:
378.45
Product Type:
Inhibitor
Purity:
98%
Molecular Formula: C31H29Cl2F2N3O4
Formula Weight: 616.49
Product Type: Inhibitor
Purity: 98%
Molecular Formula:
C31H29Cl2F2N3O4
Formula Weight:
616.49
Product Type:
Inhibitor
Purity:
98%
Molecular Formula: C20H23N3O
Formula Weight: 321.42
Product Type: Inhibitor
Purity: 98%
Molecular Formula:
C20H23N3O
Formula Weight:
321.42
Product Type:
Inhibitor
Purity:
98%
Molecular Formula: C15H13NO
Formula Weight: 223.28
Product Type: Inhibitor
Purity: 98%
Molecular Formula:
C15H13NO
Formula Weight:
223.28
Product Type:
Inhibitor
Purity:
98%