7166835

Tocris™ AZD 5363

Potent pan-AKT inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Synonym

Capivasertib

Formula Weight

428.92

Purity

98%

Molecular Formula

C21H25ClN6O2

Product Type

Inhibitor

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Description

  • AZD 5363 is a potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively)
  • Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively)
  • Inhibits growth of tumor cell lines in vitro , particularly breast, endometrial, gastric, hematologic and prostate cancers
  • Inhibits growth of human tumor xenografts in mice
  • Enhances in vivo antitumor effects of Docetaxel (Cat
  • No
  • 4056) and Lapatinib (Cat
  • No
  • 6811)
  • Orally bioavailable.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

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