7182919
Tocris Bioscience™ AS 1842856
Potent and selective Foxo1 inhibitor; orally bioavailable
Manufacturer: Fischer Scientific
CAS Number: 836620-48-5
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Chemical Name or Material
5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS
836620-48-5
Molecular Formula
C18H22FN3O3
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ AS 1842856 | Fischer Scientific | ₹ 12,727.00 | |
| | Tocris Bioscience™ AS 1842856 | Fischer Scientific | ₹ 52,065.00 | |
 | Medchemexpress LLC HY-100596 10mg , AS1842856 CAS:836620-48-5 Purity:>98% | Medchemexpress LLC | ₹ 7,849.80 | |
 | Selleck Chemical LLC AS1842856 10mg 836620-48-5 | Selleck Chemical LLC | ₹ 15,699.60 | |
 | 836620-48-5 | As1842856 | A2B Chem | ₹ 2,492.00 - ₹ 5,53,313.00 |
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Description
- Potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively
- Regulates gluconeogenesis both in vitro and in vivo
- Attenuates fasting plasma glucose level in diabetic db/db mice
- Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression
- Also inhibits STAT3 signaling in NSCLC
- Orally bioavailable.
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Chemical Name or Material: 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS: 836620-48-5
Molecular Formula: C18H22FN3O3
Purity: 98%
Chemical Name or Material:
5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS:
836620-48-5
Molecular Formula:
C18H22FN3O3
Purity:
98%
Chemical Name or Material: 3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
CAS: 2204290-85-5
Molecular Formula: C18H14N2O4
Purity: 98%
Chemical Name or Material:
3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
CAS:
2204290-85-5
Molecular Formula:
C18H14N2O4
Purity:
98%
Chemical Name or Material: N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
CAS: 1240516-71-5
Molecular Formula: C24H25ClN4O5S2
Purity: 98%
Chemical Name or Material:
N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
CAS:
1240516-71-5
Molecular Formula:
C24H25ClN4O5S2
Purity:
98%
Chemical Name or Material: (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
CAS: 1956356-56-1
Molecular Formula: C17H11KN2O6S2
Purity: 98%
Chemical Name or Material:
(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
CAS:
1956356-56-1
Molecular Formula:
C17H11KN2O6S2
Purity:
98%