7199103
Tocris™ DL 175
Potent and selective GPR84 agonist
Manufacturer: Fischer Scientific
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Chemical Name or Material
3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Target
Free Fatty Acid Receptor Agonists
Molecular Formula
C17H14ClNO2
Purity
98%
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Description
- DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM)
- Exhibits no significant activity in a panel of 168 other GPCRs
- Exhibits bias for G protein signaling pathways
- Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells
- Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Target: Free Fatty Acid Receptor Agonists
Molecular Formula: C17H14ClNO2
Purity: 98%
Chemical Name or Material:
3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Target:
Free Fatty Acid Receptor Agonists
Molecular Formula:
C17H14ClNO2
Purity:
98%
Chemical Name or Material: (3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target: Rho-kinase Inhibitors
Molecular Formula: C24H28N4O40.2 HCl
Purity: 98%
Chemical Name or Material:
(3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target:
Rho-kinase Inhibitors
Molecular Formula:
C24H28N4O40.2 HCl
Purity:
98%
Chemical Name or Material: (3 AS)-2-[(3 S)-1-azabicyclo[2.2.2 ]oct-3-yl]-2,3,3 A,4,5,6-hexahydro-1 H-benz[de]isoquinolin-1-one hydrochloride
Target: 5-HT3 Receptor Antagonists
Molecular Formula: C19H24N2O.HCl
Purity: 98%
Chemical Name or Material:
(3 AS)-2-[(3 S)-1-azabicyclo[2.2.2 ]oct-3-yl]-2,3,3 A,4,5,6-hexahydro-1 H-benz[de]isoquinolin-1-one hydrochloride
Target:
5-HT3 Receptor Antagonists
Molecular Formula:
C19H24N2O.HCl
Purity:
98%
Chemical Name or Material: (2 Z)-2 [[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5 H-imidazo[2,1-b][1,3 ]thiazin-3(2 H)-one
Target: Additional Cannabinoid-related Compounds
Molecular Formula: C20H17ClN2O2S
Purity: 98%
Chemical Name or Material:
(2 Z)-2 [[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5 H-imidazo[2,1-b][1,3 ]thiazin-3(2 H)-one
Target:
Additional Cannabinoid-related Compounds
Molecular Formula:
C20H17ClN2O2S
Purity:
98%