7236998
Tocris Bioscience™ T4
Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3
Manufacturer: Fischer Scientific
CAS Number: 785708-33-0
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Chemical Name or Material
6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2 H)-yl)methyl)]quinazolin-4(3 H)-one
Target
DNA, RNA and Protein Synthesis Compounds
Purity
0.98
CAS
785708-33-0
Molecular Formula
C22H23N3O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ T4 | Fischer Scientific | ₹ 12,306.95 | |
| | Tocris Bioscience™ T4 | Fischer Scientific | ₹ 51,510.54 | |
 | Sigma Aldrich Fine Chemicals Biosciences Photoregulin3 >=98% (HPLC) | 785708-33-0 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 12,367.70 | |
| | Sigma Aldrich Fine Chemicals Biosciences Photoregulin3 >=98% (HPLC) | 785708-33-0 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 39,828.18 |
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Description
- T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively)
- T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling
- T4 exhibits no inhibitory activity against a panel of 414 kinases
- T4 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa
- T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC50 = 0.07 μM).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2 H)-yl)methyl)]quinazolin-4(3 H)-one
Target: DNA, RNA and Protein Synthesis Compounds
Purity: 0.98
CAS: 785708-33-0
Molecular Formula: C22H23N3O3
Chemical Name or Material:
6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2 H)-yl)methyl)]quinazolin-4(3 H)-one
Target:
DNA, RNA and Protein Synthesis Compounds
Purity:
0.98
CAS:
785708-33-0
Molecular Formula:
C22H23N3O3
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