74-571-0
Tocris Bioscience™ CAM 833
Manufacturer: Tocris Bioscience™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-571-0-Each-of-1 | In Stock | ₹ 31,506.00 |
74-571-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,506.00
GST (18%): ₹ 5,671.08
Total Price: ₹ 37,177.08
Chemical Name or Material
N-(2-((2 S,4 R)-2-((-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
Target
DNA, RNA and Protein Synthesis Compounds
Purity
0.98
Quantity
10 mg
Molecular Formula
C26H26ClFN4O5
Related Products
Description
- CAM 833 a selective orthosteric inhibitor of the BRCA2-RAD51 interaction (Kd of 366 nM; IC50 of 6 μM)
- CAM 833 has no significant off-target interactions when screened at 10 μM in the Cerep ExpresSPanel
- It inhibits DNA recombinase RAD51-mediated homologous recombination through binding to RAD51 at the same site as the BRCA2 FxxA motif
- In cells, CAM 833 suppresses the assembly of RAD51 into damage-induced filaments at the sites of DNA damage
- CAM 833 potentiates radiation-induced cytotoxicity and poly-ADP ribose polymerase (PARP)1 inhibitor- induced growth suppression in BRCA2-wild-type cells
- The product is metabolically stable, does not significantly inhibit CYP450 enzymes, and is suitable for in vivo investigation.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: N-(2-((2 S,4 R)-2-((-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
Target: DNA, RNA and Protein Synthesis Compounds
Purity: 0.98
Quantity: 10 mg
Molecular Formula: C26H26ClFN4O5
Chemical Name or Material:
N-(2-((2 S,4 R)-2-((-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
Target:
DNA, RNA and Protein Synthesis Compounds
Purity:
0.98
Quantity:
10 mg
Molecular Formula:
C26H26ClFN4O5
Chemical Name or Material: 1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
Target: Bromodomain Inhibitors
Purity: 0.98
Quantity: 10 mg
Molecular Formula: C19H25N5O3
Chemical Name or Material:
1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
Target:
Bromodomain Inhibitors
Purity:
0.98
Quantity:
10 mg
Molecular Formula:
C19H25N5O3
Chemical Name or Material: 1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
Target: Bromodomain Inhibitors
Purity: 0.98
Quantity: 50 mg
Molecular Formula: C19H25N5O3
Chemical Name or Material:
1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
Target:
Bromodomain Inhibitors
Purity:
0.98
Quantity:
50 mg
Molecular Formula:
C19H25N5O3
Chemical Name or Material: (2 S,4 R)-1-(-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target: Active Degraders
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C51H57F2N9O7S2
Chemical Name or Material:
(2 S,4 R)-1-(-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target:
Active Degraders
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C51H57F2N9O7S2