7250156
Tocris Bioscience™ ABX 464
HIV RNA splicing modulator
Manufacturer: Fischer Scientific
CAS Number: 1258453-75-6
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Chemical Name or Material
8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target
DNA, RNA and Protein Synthesis Compounds
Purity
0.98
CAS
1258453-75-6
Molecular Formula
C16H10ClF3N2O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ ABX 464 | Fischer Scientific | ₹ 20,743.17 | |
| | Tocris Bioscience™ ABX 464 | Fischer Scientific | ₹ 87,041.90 | |
 | Medchemexpress LLC HY-100870 5mg Medchemexpress, ABX464 CAS:1258453-75-6 Purity:>98% | Medchemexpress LLC | ₹ 10,331.37 | |
 | 1258453-75-6 | ABX-464 | A2B Chem | ₹ 7,529.28 - ₹ 25,924.68 |
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Description
- ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing
- ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance
- ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages
- It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells
- In HIV infected humanized mice, treatment with ABX 464 reduces viral load
- Anti-inflammatory.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target: DNA, RNA and Protein Synthesis Compounds
Purity: 0.98
CAS: 1258453-75-6
Molecular Formula: C16H10ClF3N2O
Chemical Name or Material:
8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target:
DNA, RNA and Protein Synthesis Compounds
Purity:
0.98
CAS:
1258453-75-6
Molecular Formula:
C16H10ClF3N2O
Chemical Name or Material: 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Target: ALK/CD246
Purity: 0.98
CAS: __
Molecular Formula: C24H26FN3O20.2 HCl
Chemical Name or Material:
1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Target:
ALK/CD246
Purity:
0.98
CAS:
__
Molecular Formula:
C24H26FN3O20.2 HCl
Chemical Name or Material: 4-Fluoro-3-[[[5-(1-methyl-1 H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Target: DDR1/DDR2
Purity: 0.98
CAS: 2442597-56-8
Molecular Formula: C24H19F4N5O2
Chemical Name or Material:
4-Fluoro-3-[[[5-(1-methyl-1 H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Target:
DDR1/DDR2
Purity:
0.98
CAS:
2442597-56-8
Molecular Formula:
C24H19F4N5O2
Chemical Name or Material: N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2 H-1-benzopyran-3-carboxamide
Target: beta-Catenin
Purity: 0.98
CAS: 943083-58-7
Molecular Formula: C22H23N3O3
Chemical Name or Material:
N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2 H-1-benzopyran-3-carboxamide
Target:
beta-Catenin
Purity:
0.98
CAS:
943083-58-7
Molecular Formula:
C22H23N3O3