7250154
Tocris Bioscience™ STING agonist C53
Pan-polymorph STING agonist
Manufacturer: Fischer Scientific
CAS Number: 2259624-71-8
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Chemical Name or Material
1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
Target
STING Agonists
Purity
0.98
CAS
2259624-71-8
Molecular Formula
C25H19ClF4N2O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ STING agonist C53 | Fischer Scientific | ₹ 18,352.62 | |
| | Tocris Bioscience™ STING agonist C53 | Fischer Scientific | ₹ 76,747.32 | |
 | eMolecules Medchem Express / STING agonist-12 / 5mg / 719836172 / HY-147010 / / 2259624-71-8 / [null] / 490.880 / C25H19ClF4N2O2 | eMolecules | ₹ 12,594.43 |
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Description
- STING agonist C53 is an activator of human STING (EC50 = 185 nM)
- It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP
- STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively)
- It induces phosphorylation of STING variants in human tumor cell lines and PBMCs
- STING agonist C53 is active at human but not mouse STING
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
Target: STING Agonists
Purity: 0.98
CAS: 2259624-71-8
Molecular Formula: C25H19ClF4N2O2
Chemical Name or Material:
1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
Target:
STING Agonists
Purity:
0.98
CAS:
2259624-71-8
Molecular Formula:
C25H19ClF4N2O2
Chemical Name or Material: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target: CD117/c-kit
Purity: 0.98
CAS: 790299-79-5
Molecular Formula: C28H30N6OS
Chemical Name or Material:
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target:
CD117/c-kit
Purity:
0.98
CAS:
790299-79-5
Molecular Formula:
C28H30N6OS
Chemical Name or Material: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target: DNA, RNA and Protein Synthesis Compounds
Purity: 0.98
CAS: 1258453-75-6
Molecular Formula: C16H10ClF3N2O
Chemical Name or Material:
8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target:
DNA, RNA and Protein Synthesis Compounds
Purity:
0.98
CAS:
1258453-75-6
Molecular Formula:
C16H10ClF3N2O
Chemical Name or Material: 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Target: ALK/CD246
Purity: 0.98
CAS: __
Molecular Formula: C24H26FN3O20.2 HCl
Chemical Name or Material:
1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Target:
ALK/CD246
Purity:
0.98
CAS:
__
Molecular Formula:
C24H26FN3O20.2 HCl