74-255
Tocris Bioscience™ CG 428
Manufacturer: Tocris Bioscience™
CAS Number: 2412055-93-5
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-255-Each-of-1 | In Stock | ₹ 43,076.00 |
74-255 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,076.00
GST (18%): ₹ 7,753.68
Total Price: ₹ 50,829.68
Chemical Name or Material
2-(2,6-Dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2 R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1 H-isoindole-1,3(2 H)-dione
Quantity
5 mg
Molecular Formula
C43H43FN10O6
CAS
2412055-93-5
Target
Active Degraders
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | CG 428 | Aaron Chemicals LLC | -- |
Related Products
Description
- CG 428 is a potent tropomyosin receptor kinase (TRK) Degrader (uSMITETM) (DC50 = 0.36 nM)
- CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide (Cat
- No
- 6302)
- CG 428 shows selectivity for TRKA over TRKC and TRKB (Kd values = 1nM, 4.2 nM and 28 nM, respectively)
- Inhibits growth of KM12 colon cancer cells (IC50 =2.9 nM) and is bioavailable
- Negative control also available, CG 428-Neg (Cat
- No
- 7426).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 2-(2,6-Dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2 R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1 H-isoindole-1,3(2 H)-dione
Quantity: 5 mg
Molecular Formula: C43H43FN10O6
CAS: 2412055-93-5
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
2-(2,6-Dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2 R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1 H-isoindole-1,3(2 H)-dione
Quantity:
5 mg
Molecular Formula:
C43H43FN10O6
CAS:
2412055-93-5
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: 2-(1-Methyl-2,6-dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2 R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1 H-isoindole-1,3(2 H)-dione
Quantity: 5 mg
Molecular Formula: C44H45FN10O6
CAS: __
Target: Active Degrader Negative Controls
Purity: 0.98
Chemical Name or Material:
2-(1-Methyl-2,6-dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2 R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1 H-isoindole-1,3(2 H)-dione
Quantity:
5 mg
Molecular Formula:
C44H45FN10O6
CAS:
__
Target:
Active Degrader Negative Controls
Purity:
0.98
Chemical Name or Material: N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity: 5 mg
Molecular Formula: C42H39F2N7O8S
CAS: 2417296-82-1
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity:
5 mg
Molecular Formula:
C42H39F2N7O8S
CAS:
2417296-82-1
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity: 5 mg
Molecular Formula: C43H41F2N7O8S
CAS: 2417296-83-2
Target: Active Degrader Negative Controls
Purity: 0.98
Chemical Name or Material:
N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity:
5 mg
Molecular Formula:
C43H41F2N7O8S
CAS:
2417296-83-2
Target:
Active Degrader Negative Controls
Purity:
0.98