74-275
Tocris Bioscience™ CG 858
Manufacturer: Tocris Bioscience™
CAS Number: 2417296-82-1
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-275-Each-of-1 | In Stock | ₹ 42,095.52 |
74-275 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,095.52
GST (18%): ₹ 7,577.194
Total Price: ₹ 49,672.714
Chemical Name or Material
N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity
5 mg
Molecular Formula
C42H39F2N7O8S
CAS
2417296-82-1
Target
Active Degraders
Purity
0.98
Related Products
Description
- CG 858 is a selective BRAF-V600E protein Degrader (uSMITETM)
- CG 858 comprises the BRAF kinase inhibitor vemurafenib linked to the E3 ligase ligand Thalidomide (Cat
- No
- 0652)
- CG 858 dose-dependently degrades BRAF-V600E but not wild type BRAF, and reduces cell viability and colony formation in HT-29 and A375 cells (DC50 values are 124 nM and 500 nM, respectively)
- Exhibits 88% degradation at 500 nM
- CG 858 also impairs melanoma cell growth
- CG 858 negative control (Cat
- No
- 7428) also available.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity: 5 mg
Molecular Formula: C42H39F2N7O8S
CAS: 2417296-82-1
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity:
5 mg
Molecular Formula:
C42H39F2N7O8S
CAS:
2417296-82-1
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity: 5 mg
Molecular Formula: C43H41F2N7O8S
CAS: 2417296-83-2
Target: Active Degrader Negative Controls
Purity: 0.98
Chemical Name or Material:
N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
Quantity:
5 mg
Molecular Formula:
C43H41F2N7O8S
CAS:
2417296-83-2
Target:
Active Degrader Negative Controls
Purity:
0.98
Chemical Name or Material: N,N'-(11-((2-((-1-((2 S,4 R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-(-4-(4-chlorophenyl)-2,3,9-tri
Quantity: 5 mg
Molecular Formula: C79H98Cl2N14O13S3
CAS: __
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
N,N'-(11-((2-((-1-((2 S,4 R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-(-4-(4-chlorophenyl)-2,3,9-tri
Quantity:
5 mg
Molecular Formula:
C79H98Cl2N14O13S3
CAS:
__
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Quantity: 25 mg
Molecular Formula: C17H18N6O5
CAS: 2271036-44-1
Target: Degrader Building Blocks
Purity: 0.95
Chemical Name or Material:
4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Quantity:
25 mg
Molecular Formula:
C17H18N6O5
CAS:
2271036-44-1
Target:
Degrader Building Blocks
Purity:
0.95