SML1107
SGC0946
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1561178-17-3
Synonym(S): 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-Pyrrolo[2,3-d]pyrimidin-4-amine
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML1107-5-MG | In Stock | ₹ 15,533.88 |
| 25 MG | SML1107-25-MG | In Stock | ₹ 40,864.38 |
SML1107 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 15,533.88
GST (18%): ₹ 2,796.098
Total Price: ₹ 18,329.978
Quality Level
100
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
BrC1=CN([C@@H]2O[C@H](CN(CCCNC(NC3=CC=C(C(C)(C)C)C=C3)=O)C(C)C)[C@@H](O)[C@H]2O)C4=C1C(N)=NC=N4
InChI
1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChI key
IQCKJUKAQJINMK-HUBRGWSESA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ SGC 0946 | Tocris™ | ₹ 8,833.21 | |
 | Medchemexpress LLC HY-15650 50mg , SGC0946 CAS:1561178-17-3 Purity:>98% | Medchemexpress LLC | ₹ 28,748.16 | |
 | Sigma Aldrich Fine Chemicals Biosciences SGC0946 >=98% (HPLC) | 1561178-17-3 | MFCD26523136 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 16,560.14 | |
| | Sigma Aldrich Fine Chemicals Biosciences SGC0946 >=98% (HPLC) | 1561178-17-3 | MFCD26523136 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 48,769.20 | |
 | 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]- | Aaron Chemicals LLC | ₹ 2,053.44 - ₹ 78,372.96 | |
 | 1561178-17-3 | 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]- | A2B Chem | ₹ 4,363.56 - ₹ 54,758.40 |
Related Products
Description
- Biochem/physiol Actions: SGC0946 is a potent and selective inhibitor of Histone H3-lysine79 (H3K79) methyltransferase DOT1L with an IC50 of 0.3 nM in a radioactive enzyme assay, and over 100-fold selectivity for DOT1L over other histone methyltransferases. In cell studies, SGC0946 reduces H3K79 dimethylation with an IC50 of 2.6 nM in A431 cells and 8.8 nM in MCF10A cells. SGC0946 was found to selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia. For full characterization details, please visit the SGC0946 probe summary on the Structural Genomics Consortium (SGC) website.SGC0649 is the negative control for the active probe, SGC0946. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: SGC0946 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
- Other Notes: SGC0946 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC0946 probe summary on the Chemical Probes Portal website.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 20 mg/mL, clear
storage temp.: −20°C
SMILES string: BrC1=CN([C@@H]2O[C@H](CN(CCCNC(NC3=CC=C(C(C)(C)C)C=C3)=O)C(C)C)[C@@H](O)[C@H]2O)C4=C1C(N)=NC=N4
InChI: 1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChI key: IQCKJUKAQJINMK-HUBRGWSESA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 20 mg/mL, clear
storage temp.:
−20°C
SMILES string:
BrC1=CN([C@@H]2O[C@H](CN(CCCNC(NC3=CC=C(C(C)(C)C)C=C3)=O)C(C)C)[C@@H](O)[C@H]2O)C4=C1C(N)=NC=N4
InChI:
1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChI key:
IQCKJUKAQJINMK-HUBRGWSESA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC=C(OC)C(Cl)=C4)N3C[C@@H](N5CCOCC5)C)=C2
InChI: 1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChI key: GEPYBHCJBORHCE-SFHVURJKSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC=C(OC)C(Cl)=C4)N3C[C@@H](N5CCOCC5)C)=C2
InChI:
1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChI key:
GEPYBHCJBORHCE-SFHVURJKSA-N
Quality Level: 200
Assay: ≥95% (HPLC)
form: powder
color: __
solubility: DMSO: soluble
storage temp.: −20°C
SMILES string: O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O
InChI: 1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
InChI key: TZYWCYJVHRLUCT-ZRBLBEILSA-N
Quality Level:
200
Assay:
≥95% (HPLC)
form:
powder
color:
__
solubility:
DMSO: soluble
storage temp.:
−20°C
SMILES string:
O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O
InChI:
1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
InChI key:
TZYWCYJVHRLUCT-ZRBLBEILSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 5 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
InChI: 1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key: YUNQZQREIHWDQT-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 5 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
InChI:
1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key:
YUNQZQREIHWDQT-UHFFFAOYSA-N