53-048-60001

MilliporeSigma™ Calbiochem™ p38 MAP Kinase Inhibitor XX, FGA-19

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 53-048-60001-Each-of-1 In Stock ₹ 15,743.04

53-048-60001 - Each of 1

₹ 15,743.04

In Stock

Quantity

1

Base Price: ₹ 15,743.04

GST (18%): ₹ 2,833.747

Total Price: ₹ 18,576.787

Color

Orange Red

Target Proteins

p38 MAPK

Solubility

DMSO

Form

Powder

Description

98% by HPLC

Molecular Formula

C13H9ClN4O3

Content And Storage

Protect from light

Quantity

10 mg

Related Products

Img

MilliporeSigma™

53-046-30001

--

Img

MilliporeSigma™

54-021-810MG

--

Img

MilliporeSigma™

50-621-60001

--

Img

MilliporeSigma™

50-050-60001

--

Img

MilliporeSigma™

53-065-00001

--

Img

MilliporeSigma™

50-071-30001

--

Img

MilliporeSigma™

50-437-90001

--

Img

MilliporeSigma™

50-604-70001

--

Description

  • A cell-permeable, benzoxadiazole compound designed to target p38 c-terminal docking domain that mediates interactions with upstream regulators and downstream substrates outside p38 active center
  • Selectively inhibits MEF-2A phosphorylation by activated p38α (IC 50 = 6.31μM; [p38] = 1 nM, [MEF-2a] = 10 nM, [ATP] = 25μM) with little or no potency against a panel of other kinases or the docking site interaction-independent MBP phosphorylation by p38
  • Shown to inhibit LPS-stimulated phosphorylation of p38, MK2, and Hsp27 in THP-1 cells (1 to 5μM; 1 h drug preincubation), while reduced inhibition against JNK1 and Erk1/2 is only observed at a high concentration of 5μM
  • Although SB203580 (Cat
  • Nos
  • 559389, 559395, and 559398) exhibits similar potency as FGA-19 in inhibiting LPS-induced TNFα secretion in THP-1 cultures in vitro , only FGA-19 (1μg/5μL/mouse), but not SB203580 (up to 5μg/mouse), intrathecal injection results in lasting (>5 days) reduction of heat sensitivity of paws received carrageenan injection among either wild-type or LysM-GRK2 +/- mice in vivo .

Compare Similar Items

Show Difference

Img

MilliporeSigma™

53-048-60001

--


Color:
Orange Red

Target Proteins:
p38 MAPK

Solubility:
DMSO

Form:
Powder

Description:
98% by HPLC

Molecular Formula:
C13H9ClN4O3

Content And Storage:
Protect from light

Quantity:
10 mg

Img

MilliporeSigma™

53-048-70001

--


Color:
Yellow

Target Proteins:
Cdk4 & Cdk6

Solubility:
H2O

Form:
Liquid

Description:
97% by HPLC

Molecular Formula:
C24H29N7O2·HCl

Content And Storage:
Avoid Freeze-Thaw Cycles, Protect from Light

Quantity:
5 mg

Img

Tocris Bioscience™

53-051-0

--


Color:
__

Target Proteins:
__

Solubility:
__

Form:
__

Description:
__

Molecular Formula:
__

Content And Storage:
__

Quantity:
10 mg

Img

MilliporeSigma™

53-051-00001

--


Color:
Dark Yellow

Target Proteins:
mitochondria

Solubility:
DMSO

Form:
Powder

Description:
97% by HPLC

Molecular Formula:
C17H15N7

Content And Storage:
Protect from light

Quantity:
10 mg