Anti-Na+/K+ ATPase α-1 Antibody

Description

• General description: Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html)
• Specificity: Expected to cross-react with Rat-100%, Mouse-99%; human, pig, rabbit, monkey-96%.
• Immunogen: Epitope: Cytoplasmic domain
• Application: Research CategoryNeuroscience
• Quality: Routinely evaluated by Immunoprecipitation on rat brain microsomal prep. lysate.
• Target description: 112 kDa
• Physical form: Format: Purified
• Storage and Stability: Stable for 1 year at 2-8ºC from date of receipt.
• Analysis Note: ControlRat Brain Microsomal Prep. lysate.
• Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
• Legal Information: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.