Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor™ 488

Description

• General description: Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
• Specificity: Broad species cross-reactivity is expected.
• Immunogen: A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3.
• Application: Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Alexa Fluor™ 488, is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,is labeled with Alexa Fluor 488 and validated for use in FC.
• Quality: Evaluated by Flow Cytometry with Jurkat cells.
• Target description: 17 kDa observed
• Physical form: Protein G Purified
• Storage and Stability: Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.
• Analysis Note: ControlJurkat Cells
• Legal Information: ALEXA FLUOR is a trademark of Life Technologies
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.