Anti-SRGAP3 antibody produced in rabbit

Description

• General description: Anti-SRGAP3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human SRGAP3 (GeneID: 9901), conjugated to KLH. SRGAP3 (Slit-ROBO Rho GTPase-activating protein 3, also known as MEGAP, is a GTPase activating protein, that belongs to the Slit-ROBO GAPs (SRGAPs) family. It is predominantly expressed in the brain during embryonic development and in the adult brain, specifically in neurons of the hippocampus and cortex. SRGAP3 exists as two isoforms SRGAP3A and SRGAP3B.
• Application: Anti-SRGAP3 antibody produced in rabbit has been used in immunofluorescence and immunoblotting.
• Biochem/physiol Actions: SRGAP3 (Slit-ROBO Rho GTPase-activating protein 3) negatively regulates cell migration, by inhibiting the activity of Rac1 and Cdc42. SRGAP3/MEGAP has been associated with severe mental retardation in several patients. It plays pivotal roles in learning and memory. SRGAP3/WRP interacts directly to WAVE-1 through its Src homology domain and specifically inhibits Rac function in vivo.Induced expression of SRGAP3 inhibits Rac1 and Cdc42 activity and impedes cell migration by impairing actin and microtubule dynamics and formation of focal complexes.
• Physical form: Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
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