SAB4200757
Anti-PLA2R antibody, Mouse monoclonal
clone 12-6-5, purified from hybridoma cell culture
Manufacturer: Sigma Aldrich
Synonym(S): Anti-180 kDa secretory phospholipase A2 receptor, Anti-C-type lectin domain family 13 member C, Anti-M-type receptor, Anti-PLA2-R, Anti-PLA2R, Anti-Secretory phospholipase A2 receptor
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 μL | SAB4200757-100-μL | In Stock | ₹ 55,511.10 |
SAB4200757 - 100 μL
In Stock
Quantity
1
Base Price: ₹ 55,511.10
GST (18%): ₹ 9,991.998
Total Price: ₹ 65,503.098
biological source
mouse
Quality Level
200
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
12-6-5, monoclonal
form
buffered aqueous solution
mol wt
~180 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
flow cytometry: suitableimmunoblotting: 1-2 μg/mL using partial recombinant human PLA2R1 protein (predicted ~150kDa)immunofluorescence: suitableimmunohistochemistry: suitable
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Description
- General description: Anti-PLA2R antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the 12-6-5 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with recombinant fragment of human PLA2R corresponding to extracellular sequence NC3. Secretory phospholipase A2 receptor (PLA2R) is 180 kDa and is a type I transmembrane glycoprotein member of the mannose receptor (MR) family. Large extracellular glycosylated region comprising an N-terminal cysteine-rich domain (CysR), a fibronectin-like type II domain (FnII), and eight to ten C-type lectin-like domains (CTLD).
- Immunogen: Human PLA2R extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3)
- Application: Anti-PLA2R antibody has been used inimmunoblottingimmunofluorescenceflow Cytometryimmunohistochemistry
- Biochem/physiol Actions: Secretory phospholipase A2 receptor (PLA2R) acts as a receptor for secretory phosholipase A2 (sPLA2) allowing its removal from circulation, thus regulating its biological effect. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipase A2 (sPLA2) from the blood, including group sPLA2-X and a snake venom sPLA2. The soluble circulating form of PLA2R is constitutively present as an endogenous inhibitor of sPLA2s. PLA2R is expressed in kidney podocytes of normal human glomeruli, in idiopathic membranous nephropathy (IMN) patients PLA2R is colocalized to immune deposits in glomeruli along with IgG4.
- Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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biological source: mouse
Quality Level: 200
antibody form: purified from hybridoma cell culture
antibody product type: primary antibodies
clone: 12-6-5, monoclonal
form: buffered aqueous solution
mol wt: ~180 kDa
species reactivity: human
concentration: ~1 mg/mL
technique(s): flow cytometry: suitableimmunoblotting: 1-2 μg/mL using partial recombinant human PLA2R1 protein (predicted ~150kDa)immunofluorescence: suitableimmunohistochemistry: suitable
biological source:
mouse
Quality Level:
200
antibody form:
purified from hybridoma cell culture
antibody product type:
primary antibodies
clone:
12-6-5, monoclonal
form:
buffered aqueous solution
mol wt:
~180 kDa
species reactivity:
human
concentration:
~1 mg/mL
technique(s):
flow cytometry: suitableimmunoblotting: 1-2 μg/mL using partial recombinant human PLA2R1 protein (predicted ~150kDa)immunofluorescence: suitableimmunohistochemistry: suitable
biological source: mouse
Quality Level: 200
antibody form: purified from hybridoma cell culture
antibody product type: primary antibodies
clone: LN-6, monoclonal
form: buffered aqueous solution
mol wt: ~58 kDa
species reactivity: rat, human, porcine, monkey, bovine, canine, mouse, rabbit, hamster
concentration: ~1 mg/mL
technique(s): __
biological source:
mouse
Quality Level:
200
antibody form:
purified from hybridoma cell culture
antibody product type:
primary antibodies
clone:
LN-6, monoclonal
form:
buffered aqueous solution
mol wt:
~58 kDa
species reactivity:
rat, human, porcine, monkey, bovine, canine, mouse, rabbit, hamster
concentration:
~1 mg/mL
technique(s):
__
biological source: mouse
Quality Level: 200
antibody form: purified from hybridoma cell culture
antibody product type: primary antibodies
clone: NOS-IN, monoclonal
form: buffered aqueous solution
mol wt: ~130 kDa
species reactivity: human, mouse, rat, plant
concentration: ~1.0 mg/mL
technique(s): flow cytometry: suitableimmunoblotting: 2-4 μg/mL using mouse macrophage RAW 264.7 cell line activated with lipopolysaccharide (LPS) and interferon-γimmunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
biological source:
mouse
Quality Level:
200
antibody form:
purified from hybridoma cell culture
antibody product type:
primary antibodies
clone:
NOS-IN, monoclonal
form:
buffered aqueous solution
mol wt:
~130 kDa
species reactivity:
human, mouse, rat, plant
concentration:
~1.0 mg/mL
technique(s):
flow cytometry: suitableimmunoblotting: 2-4 μg/mL using mouse macrophage RAW 264.7 cell line activated with lipopolysaccharide (LPS) and interferon-γimmunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
biological source: rabbit
Quality Level: 200
antibody form: affinity isolated antibody
antibody product type: primary antibodies
clone: polyclonal
form: buffered aqueous solution
mol wt: ~95 kDa
species reactivity: human
concentration: ~1 mg/mL
technique(s): __
biological source:
rabbit
Quality Level:
200
antibody form:
affinity isolated antibody
antibody product type:
primary antibodies
clone:
polyclonal
form:
buffered aqueous solution
mol wt:
~95 kDa
species reactivity:
human
concentration:
~1 mg/mL
technique(s):
__