ZRB1224

Anti-uPAR Antibody, clone 2G10 , ZooMAb® Rabbit Monoclonal

recombinant, expressed in HEK 293 cells

Manufacturer: Sigma Aldrich

Synonym(S): CD87, Monocyte activation antigen Mo3, U-PAR, Urokinase plasminogen activator surface receptor

Select a Size

Pack Size SKU Availability Price
25 μL ZRB1224-25-μL In Stock ₹ 20,810.01
4 X 25 μL ZRB1224-4-X-25-μL In Stock ₹ 42,850.00

ZRB1224 - 25 μL

₹ 20,810.01

In Stock

Quantity

1

Base Price: ₹ 20,810.01

GST (18%): ₹ 3,745.802

Total Price: ₹ 24,555.812

biological source

rabbit (recombinant)

Quality Level

200

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

2G10, recombinant monoclonal

product line

ZooMAb® learn more

form

lyophilized

mol wt

observed mol wt ~45 kDa

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Description

  • General description: We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
  • Specificity: Clone 2G10 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects human Urokinase plasminogen activator surface receptor (uPAR).
  • Immunogen: A recombinant fragment corresponding the first 277 amino acids from human Urokinase plasminogen activator surface receptor (uPAR).
  • Application: Anti-uPAR, clone 2G10 ZooMAb, Cat. No. ZRB1224, is a Rabbit monoclonal antibody that targets uPAR and has been tested for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Inhibition Assay, and Western Blotting.
  • Target description: Urokinase plasminogen activator surface receptor (UniProt: Q03405; also known as U-PAR, uPAR. Monocyte activation antigen Mo3, CD87) is encoded by the PLAUR (also known as MO3, UPAR) gene (Gene ID: 5329) in human. uPAR is a GPI-anchored cell membrane receptor for urokinase plasminogen activator (uPA), an enzyme responsible for the activation of plasmin and degradation of extracellular matrix components. It is also a subject to negative-feedback regulation by U-PA, which cleaves it into an inactive form. uPAR is synthesized with a signal peptide (aa 1-22) and a propeptide (aa 306-335), which are subsequently cleaved off to produce the mature form. The mature form has three homologous domains known as DI, DII, and DIII. Higher expression of uPAR has been reported in many human cancers, including non-small cell lung cancer and colorectal cancer and it correlates with a poor prognosis and early invasion and metastasis. uPAR, through integrins interaction, is reported to play a crucial role in activating Src, FAK and paxillin, which are considered as critical mediators of cell migration. In addition, via its interaction with chemotaxis receptors for fMet-lleu-Phe, it mediates both uPA and fMLF-dependent cell migration. uPAR has also been implicated in cross-talk with EGFR, which mediates the shift from tumor cell dormancy to proliferation. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals. (Ref.: Di Mauro, C., et al. (2017). Sci. Rep. 7; Article 9388).
  • Physical form: Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.
  • Reconstitution: 300 μg/mL after reconstitution at 25 μL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
  • Storage and Stability: Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.
  • Legal Information: ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany
  • Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

SAFETY INFORMATION

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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