IL-20RB Monoclonal Antibody (20RNTC), eBioscience™, Invitrogen™

Description

• Description: This 20RNTC monoclonal antibody recognizes mouse and human IL-20R2 (interleukin-20 receptor 2, IL-20Rb) in either of its two heterodimeric complexes formed by pairing with IL-20R1 or IL-22R1
• IL-20R2 belongs to the class II cytokine receptor family that shares a characteristic pattern of cysteine, proline and tryptophan residues in the extracellular domain
• IL-20R2 paired with IL-20R1 forms a receptor that binds IL-20, IL-19, or IL-24
• IL-20R2 paired with IL22R1 forms a receptor that binds IL-20 or IL-24
• The IL-20R complex signals primarily via the JAK-STAT pathway
• IL-20R2 is found predominantly on cells of epithelial origin such as gut and skin and can be upregulated during inflammation
• Immunofluorescent staining of A375 cells reveals a punctate staining pattern at the cell membrane, as well as diffuse, cytoplasmic staining that is likely associated with protein synthesis and transport in the endoplasmic reticulum and golgi
• Applications Reported: This 20RNTC antibody has been reported for use in immunocytochemistry, immunoblotting (WB) and flow cytometric analysis
• Applications Tested: This 20RNTC antibody has been tested by immunofluorescent staining and flow cytometric analysis of fixed and permeabilized A375 cells
• This can be used between 1-10 μg/mL
• Purity: Greater than 90%, as determined by SDS-PAGE
• Aggregation: Less than 10%, as determined by HPLC
• Filtration: 0.2 μm post-manufacturing filtered
• IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009].