14-901-537
Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-901-537-Each-of-1 | In Stock | ₹ 1,17,388.32 |
14-901-537 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,17,388.32
GST (18%): ₹ 21,129.898
Total Price: ₹ 1,38,518.218
Antigen
Phospho-BTK/ITK (Tyr551, Tyr511)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P35991, Q03526, Q06187, Q08881
Gene Symbols
BTK, ITK
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12229, 16428, 3702, 695
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone
M4G3LN
Conjugate
Unconjugated
Gene
ITK
Gene Alias
agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking e
Host Species
Mouse
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- This M4G3LN MAb recognizes human and mouse Bruton's tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively
- In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family
- The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk
- Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering
- BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180
- Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively
- People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency
- Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting
- In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family
- The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk
- Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering
- BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180
- Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively
- People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.
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Antigen: Phospho-BTK/ITK (Tyr551, Tyr511)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P35991, Q03526, Q06187, Q08881
Gene Symbols: BTK, ITK
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12229, 16428, 3702, 695
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone: M4G3LN
Conjugate: Unconjugated
Gene: ITK
Gene Alias: agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking e
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG2b κ
Antigen:
Phospho-BTK/ITK (Tyr551, Tyr511)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P35991, Q03526, Q06187, Q08881
Gene Symbols:
BTK, ITK
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12229, 16428, 3702, 695
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone:
M4G3LN
Conjugate:
Unconjugated
Gene:
ITK
Gene Alias:
agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking e
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG2b κ
Antigen: CD266 (TWEAK Receptor)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q9NP84
Gene Symbols: TNFRSF12A
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 51330
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone: ITEM-1
Conjugate: Unconjugated
Gene: TNFRSF12A
Gene Alias: AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD266 (TWEAK Receptor)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q9NP84
Gene Symbols:
TNFRSF12A
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
51330
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone:
ITEM-1
Conjugate:
Unconjugated
Gene:
TNFRSF12A
Gene Alias:
AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: CD266 (TWEAK Receptor)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q9NP84
Gene Symbols: TNFRSF12A
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 51330
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone: ITEM-1
Conjugate: Unconjugated
Gene: TNFRSF12A
Gene Alias: AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD266 (TWEAK Receptor)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q9NP84
Gene Symbols:
TNFRSF12A
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
51330
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone:
ITEM-1
Conjugate:
Unconjugated
Gene:
TNFRSF12A
Gene Alias:
AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: __
Classification: __
Concentration: 50 μg/mL
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Purification Method: __
Regulatory Status: __
Gene ID (Entrez): __
Content And Storage: __
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Applications: __
Clone: __
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Gene: __
Gene Alias: __
Host Species: __
Quantity: 1 mL
Primary or Secondary: __
Target Species: __
Product Type: __
Isotype: __
Antigen:
__
Classification:
__
Concentration:
50 μg/mL
Formulation:
__
Gene Accession No.:
__
Gene Symbols:
__
Purification Method:
__
Regulatory Status:
__
Gene ID (Entrez):
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Content And Storage:
__
Form:
__
Applications:
__
Clone:
__
Conjugate:
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Gene:
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Gene Alias:
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Host Species:
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Quantity:
1 mL
Primary or Secondary:
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Target Species:
__
Product Type:
__
Isotype:
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