Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), PE, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-9078-Each-of-1 | In Stock | ₹ 36,705.24 |
50-112-9078 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,705.24
GST (18%): ₹ 6,606.943
Total Price: ₹ 43,312.183
Antigen
Phospho-BTK/ITK (Tyr551, Tyr511)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P35991, Q03526, Q06187, Q08881
Gene Symbols
BTK, ITK
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12229, 16428, 3702, 695
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
M4G3LN
Conjugate
PE
Gene
ITK
Gene Alias
agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk; xid; XLA; X-linked immune deficiency
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- Description: This M4G3LN monoclonal antibody recognizes human and mouse Bruton's tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively
- In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family
- The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk
- Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering
- BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180
- Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively
- People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency
- Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting
- Applications Reported: This M4G3LN antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family
- The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk
- Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering
- BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180
- Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively
- People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.
Compare Similar Items
Show Difference
Antigen: Phospho-BTK/ITK (Tyr551, Tyr511)
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P35991, Q03526, Q06187, Q08881
Gene Symbols: BTK, ITK
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12229, 16428, 3702, 695
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: M4G3LN
Conjugate: PE
Gene: ITK
Gene Alias: agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk; xid; XLA; X-linked immune deficiency
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG2b κ
Antigen: TCR V beta 5.1/5.2
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: __
Gene Symbols: __
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: MR9-4
Conjugate: eFluor 450
Gene: __
Gene Alias: TCR V beta5.1; TCR V beta5.2; TCRV beta 5.1; TCRV beta 5.2; TCRV beta5.1; TCRV beta5.2; Vb5.1; Vb5.2; Vbeta5.1; Vbeta5.2
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG1 κ
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Purification Method: __
Regulatory Status: __
Gene ID (Entrez): __
Content And Storage: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Gene Alias: __
Host Species: __
Quantity: 100 mL
Primary or Secondary: __
Target Species: __
Product Type: Fixation/Permeabilization Diluent
Isotype: __
