200020338
CD117 (c-Kit) Monoclonal Antibody (2B8), Brilliant Violet™ 421, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD117 (c-Kit)
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias
belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Gene Symbols
KIT
Primary or Secondary
Primary
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Clone
2B8
Applications
Flow Cytometry
Conjugate
Brilliant Violet 421
Host Species
Rat
Target Species
Mouse, Porcine
Gene Accession No.
P05532, Q2HWD6
Gene ID (Entrez)
16590, 396810
Isotype
IgG2b κ
Purification Method
Affinity chromatography
Gene
KIT
Related Products
Description
- KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor)
- KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit
- KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells
- Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism
- Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth
- c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells
- Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor
- This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway
- SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT
- c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
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Antigen: CD117 (c-Kit)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias: belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Gene Symbols: KIT
Primary or Secondary: Primary
Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
Clone: 2B8
Applications: Flow Cytometry
Conjugate: Brilliant Violet 421
Host Species: Rat
Target Species: Mouse, Porcine
Gene Accession No.: P05532, Q2HWD6
Gene ID (Entrez): 16590, 396810
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Gene: KIT
Antigen:
CD117 (c-Kit)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Gene Symbols:
KIT
Primary or Secondary:
Primary
Content And Storage:
4°, C, store in dark, DO NOT FREEZE!
Clone:
2B8
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 421
Host Species:
Rat
Target Species:
Mouse, Porcine
Gene Accession No.:
P05532, Q2HWD6
Gene ID (Entrez):
16590, 396810
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Gene:
KIT
Antigen: CD117 (c-Kit)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias: belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Gene Symbols: KIT
Primary or Secondary: Primary
Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
Clone: 2B8
Applications: Flow Cytometry
Conjugate: Brilliant Violet 786
Host Species: Rat
Target Species: Mouse, Porcine
Gene Accession No.: P05532, Q2HWD6
Gene ID (Entrez): 16590, 396810
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Gene: KIT
Antigen:
CD117 (c-Kit)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Gene Symbols:
KIT
Primary or Secondary:
Primary
Content And Storage:
4°, C, store in dark, DO NOT FREEZE!
Clone:
2B8
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 786
Host Species:
Rat
Target Species:
Mouse, Porcine
Gene Accession No.:
P05532, Q2HWD6
Gene ID (Entrez):
16590, 396810
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Gene:
KIT
Antigen: GST
Concentration: 1.0 mg/mL
Classification: Recombinant Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with proprietary stabilizer and proprietary preservative, pH 7.4
Gene Alias: activator protein 1, AP1, AP-1, cancer/testis antigen 48, c-Jun, CT48, deafness, X-linked 7, DFN7, enhancer-binding protein AP1, epididymis secretory protein Li 22, FAEES3, fatty acid ethyl ester synthase III, glutathione S-alkyltransferase, glutathione S-aralkyltransferase, glutathione S-aryltransferase, glutathione S-transferase M1, glutathione S-transferase mu 1, Glutathione S-transferase P, glutathione S-transferase pi 1, Glutathione-S-Transferase, gonad-specific transporter, GST, GST class-mu 1, GST class-pi, GST HB subunit 4, GST protein, GST Tag, GST1, GST3, GSTM1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GSTP, GSTP1, GSTP1-1, GTH4, GTM1, H-B, HB subunit 4, HEL-S-22, JUN, Jun activation domain binding protein, jun oncogene, jun proto-oncogene, Jun proto-oncogene, AP-1 transcription factor subunit, MU, MU-1, OATP6A1, OATP-I, OATPY, Organic anion-transporting polypeptide 6A1, Organic anion-transporting polypeptide I, p39, PI, Proto-oncogene c-Jun, S-(hydroxyalkyl)glutathione lyase, SLC21A19
Gene Symbols: __
Primary or Secondary: Primary
Content And Storage: -20°, C, Avoid Freeze/Thaw Cycles
Clone: GST 3-4C
Applications: Western Blot
Conjugate: HRP
Host Species: Mouse
Target Species: Tag
Gene Accession No.: __
Gene ID (Entrez): __
Isotype: IgG2b κ
Purification Method: Protein A/G
Gene: __
Antigen:
GST
Concentration:
1.0 mg/mL
Classification:
Recombinant Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with proprietary stabilizer and proprietary preservative, pH 7.4
Gene Alias:
activator protein 1, AP1, AP-1, cancer/testis antigen 48, c-Jun, CT48, deafness, X-linked 7, DFN7, enhancer-binding protein AP1, epididymis secretory protein Li 22, FAEES3, fatty acid ethyl ester synthase III, glutathione S-alkyltransferase, glutathione S-aralkyltransferase, glutathione S-aryltransferase, glutathione S-transferase M1, glutathione S-transferase mu 1, Glutathione S-transferase P, glutathione S-transferase pi 1, Glutathione-S-Transferase, gonad-specific transporter, GST, GST class-mu 1, GST class-pi, GST HB subunit 4, GST protein, GST Tag, GST1, GST3, GSTM1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GSTP, GSTP1, GSTP1-1, GTH4, GTM1, H-B, HB subunit 4, HEL-S-22, JUN, Jun activation domain binding protein, jun oncogene, jun proto-oncogene, Jun proto-oncogene, AP-1 transcription factor subunit, MU, MU-1, OATP6A1, OATP-I, OATPY, Organic anion-transporting polypeptide 6A1, Organic anion-transporting polypeptide I, p39, PI, Proto-oncogene c-Jun, S-(hydroxyalkyl)glutathione lyase, SLC21A19
Gene Symbols:
__
Primary or Secondary:
Primary
Content And Storage:
-20°, C, Avoid Freeze/Thaw Cycles
Clone:
GST 3-4C
Applications:
Western Blot
Conjugate:
HRP
Host Species:
Mouse
Target Species:
Tag
Gene Accession No.:
__
Gene ID (Entrez):
__
Isotype:
IgG2b κ
Purification Method:
Protein A/G
Gene:
__
Antigen: Tryptase
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias: TPSG1/TPSB2/TPSAB1/TPSD1
Gene Symbols: MCT7
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Clone: C13
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Canine, Porcine
Gene Accession No.: Q9N2D1
Gene ID (Entrez): 397389
Isotype: IgG2b κ
Purification Method: Protein A/G
Gene: MCT7
Antigen:
Tryptase
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias:
TPSG1/TPSB2/TPSAB1/TPSD1
Gene Symbols:
MCT7
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Clone:
C13
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Canine, Porcine
Gene Accession No.:
Q9N2D1
Gene ID (Entrez):
397389
Isotype:
IgG2b κ
Purification Method:
Protein A/G
Gene:
MCT7