3970504
Cyclin A Mouse anti-Human, Unlabeled, Clone: 25, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Cyclin A
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
25
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human
Immunogen
Human Cyclin A aa. 26-144
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- Progression of the mammalian cell cycle is regulated by phosphorylation of many key proteins
- Several classes of cyclins (A-E) act as regulatory subunits for cyclin-dependent kinases (cdks)
- These cyclin-cdk holoenzymes are essential for proper control of cell cycle progression
- They phosphorylate and regulate a variety of substrates whose activity is required for cell cycle transitions
- The temporal expression of cyclins is tightly regulated throughout the cell cycle by synthesis and degradation
- Such regulation plays a critical role in controlling the enzymatic activity of the cdks
- Cyclin A, one of the mitotic cyclins, activates Cdk2 near the start of S phase and is necessary for the initiation of DNA replication
- In mammalian somatic cells, Cyclin A is required during S phase and passage through G2
- The D and E type cyclins regulate passage through G1, while Cyclin B is a critical regulator of mitosis
- It has been shown in a number of species that mutation or disruption of normal Cyclin A expression causes cells to arrest at G2
- Cyclin A binds both the cdc2 (Cdk1) and Cdk2 kinases and may also have a role in mitotic dependence on S phase completion
- Host Species: Mouse Clone: 25 Isotype: IgG1 Species Reactivity: Human Immunogen: Human Cyclin A aa
- 26-144 Formula Weight [Chemical]: 60kDa Bioimaging, Immunofluorescence, Western Blotting
Compare Similar Items
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Antigen: Cyclin A
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 25
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Immunogen: Human Cyclin A aa. 26-144
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Cyclin A
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
25
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Immunogen:
Human Cyclin A aa. 26-144
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Cyclin B1
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: GNS-1
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Hamster, Human, Mouse
Immunogen: Human Cyclin B1 Recombinant Protein
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Cyclin B1
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
GNS-1
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Hamster, Human, Mouse
Immunogen:
Human Cyclin B1 Recombinant Protein
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: Cyclin B1
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: GNS-1
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Hamster, Human, Mouse
Immunogen: Human Cyclin B1 Recombinant Protein
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Cyclin B1
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
GNS-1
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Hamster, Human, Mouse
Immunogen:
Human Cyclin B1 Recombinant Protein
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: Cyclin B1
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: GNS-11
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse
Immunogen: Recombinant Human Cyclin B1
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Cyclin B1
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
GNS-11
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse
Immunogen:
Recombinant Human Cyclin B1
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C