3970728
gp91[phox] Mouse, Unlabeled, Clone: 53, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
gp91[phox]
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
53
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Mouse, Rat
Immunogen
Mouse gp91[phox] aa. 450-556
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- Although dormant in resting granulocytes, macrophages, and B lymphocytes, the neutrophil respiratory burst oxidase (NADPH-oxidase) generates superoxide and secondary oxygen-derived toxic products in response to bacteria or a variety of soluble stimuli
- It is an integral membrane cytochrome, b558, which consists of two subunits, gp91[phox] and p21[phox]
- Upon stimulation, cytochrome b558 forms a complex with cytosolic proteins, p67[phox], p47[phox], p40[phox], and rac2 and produces superoxide anions in a NADPH-dependent manner
- In chronic granulomatous disease (CGD), severe recurrent bacterial and fungal infections result from defective NADPH-oxidase activity
- The majority of CGD cases are caused by a defective gp91[phox] gene
- gp91[phox], implicated as a docking site for p47[phox], is membrane glycoprotein with multiple N-terminal hydrophobic domains and a hydrophilic C-terminus
- The expression of gp91[phox] is restricted to terminally differentiated phagocytes and B lymphocytes
- This cell type- and developmental stage-specific expression may be controlled by transcriptional activators, such as PU.1 and YY1, and transcriptional repressors, such as CCAAT displacement protein (CDP)
- Endogenous mouse gp91phox shows 58kDa band, instead of 91kDa observed in human
- Both mouse and human deglycosylated gp91 are 54kDa
- This difference may be due to less glycosylation sites in the mouse sequence
- Host Species: Mouse Clone: 53 Isotype: IgG1 Species Reactivity: Mouse Immunogen: Mouse gp91[phox] aa
- 450-556 Formula Weight [Chemical]: 58kDa Immunofluorescence, Western Blotting
Compare Similar Items
Show Difference
Antigen: gp91[phox]
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 53
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Mouse, Rat
Immunogen: Mouse gp91[phox] aa. 450-556
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
gp91[phox]
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
53
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Mouse, Rat
Immunogen:
Mouse gp91[phox] aa. 450-556
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: GRB2
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 81
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen: Rat GRB2 aa. 1-217
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
GRB2
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
81
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen:
Rat GRB2 aa. 1-217
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Hic5
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 34
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Human, Mouse, Rat
Immunogen: Mouse Hic-5 aa. 73-186
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Hic5
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
34
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Human, Mouse, Rat
Immunogen:
Mouse Hic-5 aa. 73-186
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Hsp60
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 24/HSP60
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse, Rat
Immunogen: Human Hsp60 aa. 1-200
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Hsp60
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
24/HSP60
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat
Immunogen:
Human Hsp60 aa. 1-200
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.