40-770-710T
MilliporeSigma™ anti-PhosphoDetect Insulin Receptor (pTyr1162/1163), Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-770-710T-Each-of-1 | In Stock | ₹ 57,678.56 |
40-770-710T - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,678.56
GST (18%): ₹ 10,382.141
Total Price: ₹ 68,060.701
Antigen
PhosphoDetect™ Insulin Receptor (pTyr1162/1163)
Classification
Polyclonal
Formulation
In Dulbecco's PBS (without Mg2+and Ca2+), 50% glycerol, 1mg/mL BSA, pH 7.3.
Immunogen
a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1162/1163phosphorylation sites of human insulin receptor
Regulatory Status
RUO
Test Specificity
Recognizes the ∽95kDaβ subunit of the insulin receptor protein phosphorylated at Tyr1162and Tyr1163in insulin receptor transfected cells. Cross-reacts with the insulin-like growth factor-1 receptor phosphorylated at Tyr1135and Tyr1136.
Content And Storage
≤ -70°C
Isotype
IgG
Applications
ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
10 Tests
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects PhosphoDetect™ Insulin Receptor (pTyr 1162/1163 ) Clone: in Human samples, and it is validated for ELISA, Immunocytochemistry, Immuno Blotting Insulin initiates its effects on cells through interaction with high-affinity cell surface glycoprotein receptors consisting of twoα (∽135kDa) and twoβ (∽95kDa) subunits linked by disulfide bonds
- Theα subunits bind insulin and theβ subunits become phosphorylated in response to insulin
- Insulin-dependent phosphorylation occurs at multiple sites near the carboxyl terminus and in the kinase domain
- The receptor protein tyrosine kinase has been implicated as the mediator of most, if not all, of the effects of insulin
- Mutations that diminish both the phosphorylation and the internalization of the insulin receptor block insulin action, as do antibodies which inhibit protein tyrosine kinase activity
- Cells from patients with diabetic syndromes, characterized by non-responsiveness to insulin, exhibit reduced insulin dependent protein tyrosine kinase activity
- Phosphorylation at Tyr 1162, Tyr 1163, and Tyr 1158 is required for the tyrosine kinase activity of the insulin receptor.
Compare Similar Items
Show Difference
Antigen: PhosphoDetect™ Insulin Receptor (pTyr1162/1163)
Classification: Polyclonal
Formulation: In Dulbecco's PBS (without Mg2+and Ca2+), 50% glycerol, 1mg/mL BSA, pH 7.3.
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1162/1163phosphorylation sites of human insulin receptor
Regulatory Status: RUO
Test Specificity: Recognizes the ∽95kDaβ subunit of the insulin receptor protein phosphorylated at Tyr1162and Tyr1163in insulin receptor transfected cells. Cross-reacts with the insulin-like growth factor-1 receptor phosphorylated at Tyr1135and Tyr1136.
Content And Storage: ≤ -70°C
Isotype: IgG
Applications: ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 10 Tests
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
PhosphoDetect™ Insulin Receptor (pTyr1162/1163)
Classification:
Polyclonal
Formulation:
In Dulbecco's PBS (without Mg2+and Ca2+), 50% glycerol, 1mg/mL BSA, pH 7.3.
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1162/1163phosphorylation sites of human insulin receptor
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽95kDaβ subunit of the insulin receptor protein phosphorylated at Tyr1162and Tyr1163in insulin receptor transfected cells. Cross-reacts with the insulin-like growth factor-1 receptor phosphorylated at Tyr1135and Tyr1136.
Content And Storage:
≤ -70°C
Isotype:
IgG
Applications:
ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
10 Tests
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: __
Classification: __
Formulation: __
Immunogen: __
Regulatory Status: __
Test Specificity: __
Content And Storage: Protect from light
Isotype: __
Applications: __
Conjugate: __
Host Species: __
Quantity: 25 g
Primary or Secondary: __
Target Species: __
Form: Crystalline Solid
Antigen:
__
Classification:
__
Formulation:
__
Immunogen:
__
Regulatory Status:
__
Test Specificity:
__
Content And Storage:
Protect from light
Isotype:
__
Applications:
__
Conjugate:
__
Host Species:
__
Quantity:
25 g
Primary or Secondary:
__
Target Species:
__
Form:
Crystalline Solid
Antigen: __
Classification: __
Formulation: __
Immunogen: __
Regulatory Status: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Conjugate: __
Host Species: __
Quantity: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Formulation:
__
Immunogen:
__
Regulatory Status:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Conjugate:
__
Host Species:
__
Quantity:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: __
Classification: __
Formulation: __
Immunogen: __
Regulatory Status: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Conjugate: __
Host Species: __
Quantity: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Formulation:
__
Immunogen:
__
Regulatory Status:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Conjugate:
__
Host Species:
__
Quantity:
__
Primary or Secondary:
__
Target Species:
__
Form:
__