57-781-510T
MilliporeSigma™ anti-PhosphoDetect Tau (pSer396), Polyclonal
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 57-781-510T-Each-of-1 | In Stock | ₹ 55,021.07 |
57-781-510T - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,021.07
GST (18%): ₹ 9,903.793
Total Price: ₹ 64,924.863
Antigen
PhosphoDetect™ Tau (pSer396)
Classification
Polyclonal
Formulation
In Dulbecco's PBS (without Mg2+and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.2-7.4.
Immunogen
a synthetic phosphopeptide corresponding to amino acids surrounding the Ser396phosphorylation site of human Tau
Regulatory Status
RUO
Test Specificity
Recognizes the ∽45-68kDa Tau protein phosphorylated at Ser396.
Content And Storage
−20°C
Isotype
IgG
Applications
Immunoblot
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
10 Tests
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects PhosphoDetect™ Tau (pSer 396 ) Clone: in Human samples, and it is validated for Immuno Blotting Tau is the microtubule-associated protein predominantly found in neurons
- It promotes assembly of tubulin into microtubules
- Tau is also a phosphoprotein and its biological activity is regulated by the degree of phosphorylation
- In the brain of Alzheimer's patients, tau is hyperphosphorylated and exists as both a cytosolic protein and as polymerized paired helical filaments (PHF)
- The PHF form the building blocks for neurofibrillary tangles that are the hallmark of AD brains
- Hyperphosphorylated tau in AD inhibits the assembly of microtubules and causes disassembly of preassembled microtubules
- Ultimately, hyperphosphorylated tau leads to the degeneration of the neurons and forms the pathogenic mechanism for Alzheimer's disease
- In addition to AD brains, neurofibrillary tangles have also been observed in brains of patients with Niemann-Pick type C (NPC) disease
- NPC is associated with the accumulation of cholesterol in several tissues and with progressive neurodegeneration
- It has recently been shown that brains of NPC patients also accumulate neurofibrillary tangles without amyloid deposits
- As in AD brains, the PHF of NPC brains are the result of hyperphosphorylation of tau
- In tau, serine 396 is one of the four most prominent phosphorylation sites used by GSK-3.
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Antigen: PhosphoDetect™ Tau (pSer396)
Classification: Polyclonal
Formulation: In Dulbecco's PBS (without Mg2+and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.2-7.4.
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Ser396phosphorylation site of human Tau
Regulatory Status: RUO
Test Specificity: Recognizes the ∽45-68kDa Tau protein phosphorylated at Ser396.
Content And Storage: −20°C
Isotype: IgG
Applications: Immunoblot
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 10 Tests
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
PhosphoDetect™ Tau (pSer396)
Classification:
Polyclonal
Formulation:
In Dulbecco's PBS (without Mg2+and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.2-7.4.
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Ser396phosphorylation site of human Tau
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽45-68kDa Tau protein phosphorylated at Ser396.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
Immunoblot
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
10 Tests
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: __
Classification: __
Formulation: __
Immunogen: __
Regulatory Status: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Conjugate: __
Host Species: __
Quantity: 50 mg
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Form: __
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Immunogen:
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Regulatory Status:
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Test Specificity:
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Content And Storage:
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Isotype:
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Applications:
__
Conjugate:
__
Host Species:
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Quantity:
50 mg
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Immunogen: __
Regulatory Status: __
Test Specificity: __
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Quantity: 25 mg
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25 mg
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Quantity: 5 mg
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Conjugate:
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Quantity:
5 mg
Primary or Secondary:
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Form:
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