4840364
CD11b Rat anti-Mouse, BB515, Clone: M1/70, BD
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11b
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Rat
Target Species
Mouse
Isotype
IgG2b κ
Purification Method
Affinity Purified
Description
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone
M1/70
Applications
Flow Cytometry
Conjugate
Brilliant Blue 515 (BB515)
Regulatory Status
RUO
Immunogen
Mouse Splenic Cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM)
- CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family
- CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3)
- Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi
- Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes
- Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface
- The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis
- Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
Compare Similar Items
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Antigen: CD11b
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Rat
Target Species: Mouse
Isotype: IgG2b κ
Purification Method: Affinity Purified
Description: Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone: M1/70
Applications: Flow Cytometry
Conjugate: Brilliant Blue 515 (BB515)
Regulatory Status: RUO
Immunogen: Mouse Splenic Cells
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD11b
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Rat
Target Species:
Mouse
Isotype:
IgG2b κ
Purification Method:
Affinity Purified
Description:
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone:
M1/70
Applications:
Flow Cytometry
Conjugate:
Brilliant Blue 515 (BB515)
Regulatory Status:
RUO
Immunogen:
Mouse Splenic Cells
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD16
Concentration: __
Classification: Monoclonal
Host Species: Mouse
Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype: IgG1 κ
Purification Method: Affinity Purified
Description: FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
Clone: 3G8
Applications: Flow Cytometry
Conjugate: Brilliant Violet 786
Regulatory Status: RUO
Immunogen: Human polymorphonuclear leukocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD16
Concentration:
__
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Description:
FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
Clone:
3G8
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 786
Regulatory Status:
RUO
Immunogen:
Human polymorphonuclear leukocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD16
Concentration: __
Classification: Monoclonal
Host Species: Mouse
Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype: IgG1 κ
Purification Method: Affinity Purified
Description: FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
Clone: 3G8
Applications: Flow Cytometry
Conjugate: Brilliant Violet 786
Regulatory Status: RUO
Immunogen: Human polymorphonuclear leukocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD16
Concentration:
__
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Description:
FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
Clone:
3G8
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 786
Regulatory Status:
RUO
Immunogen:
Human polymorphonuclear leukocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD19
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Rat
Target Species: Mouse
Isotype: IgG2a κ
Purification Method: Affinity Purified
Description: Cd19; CD19 antigen; B-lymphocyte antigen CD19
Clone: 1D3
Applications: Flow Cytometry
Conjugate: Brilliant Blue 515 (BB515)
Regulatory Status: RUO
Immunogen: Mouse CD19 Transfected Cell Line
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD19
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Rat
Target Species:
Mouse
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Description:
Cd19; CD19 antigen; B-lymphocyte antigen CD19
Clone:
1D3
Applications:
Flow Cytometry
Conjugate:
Brilliant Blue 515 (BB515)
Regulatory Status:
RUO
Immunogen:
Mouse CD19 Transfected Cell Line
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.