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50-133-47

B7-H4 Monoclonal Antibody (H74), eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Pack Size SKU Availability Price
Each 50-133-47-Each In Stock ₹ 25,894.73

50-133-47 - Each

₹ 25,894.73

In Stock

Quantity

1

Base Price: ₹ 25,894.73

GST (18%): ₹ 4,661.051

Total Price: ₹ 30,555.781

Antigen

B7-H4

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

Q7Z7D3

Gene Symbols

Vtcn1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

79679

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry

Clone

H74

Conjugate

Unconjugated

Gene

Vtcn1

Gene Alias

B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7s1; B7x; BC032925; EMBL:AAH95842.1}; FLJ22418; immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RGD1311204; RP11-229A19.4; t cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; UNQ659/PRO1291; VCTN1; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1; vtcn1 {ECO:0000312

Host Species

Mouse

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: The H74 monoclonal antibody was generated and reacts with human B7-S1, also known as B7-H4 and B7x
  • Cross reactivity of this antibody to other proteins has not been determined
  • B7S1 is a newly discovered member of the B7 family
  • It is speculated that the costimulatory regulation of T cells by B7S1 is influenced by the activation status of B cells
  • While it is reported that BTLA is a counter receptor for B7S1, further studies are needed to definitely determine the B7-H4 ligand
  • H74 stains human B7-H4 transfected cells and not peripheral blood cells
  • Exact expression pattern of B7-H4 has not been fully characterized
  • Applications Reported: This H74 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This H74 antibody has been tested by flow cytometric analysis of transient hB7-H4 transfected cells
  • This can be used at less than or equal to 0.25 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Aggregation: Less than 10%, as determined by HPLC
  • Filtration: 0.2 μm post-manufacturing filtered
  • B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity
  • Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production
  • B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response
  • B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells
  • Aberrant expression has been associated with cancers of the lung, breast and ovary in humans
  • B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses
  • Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression
  • Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).

Compare Similar Items

Show Difference

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Invitrogen

50-133-47

--

Antigen:
B7-H4
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q7Z7D3
Gene Symbols:
Vtcn1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
79679
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry
Clone:
H74
Conjugate:
Unconjugated
Gene:
Vtcn1
Gene Alias:
B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7s1; B7x; BC032925; EMBL:AAH95842.1}; FLJ22418; immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RGD1311204; RP11-229A19.4; t cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; UNQ659/PRO1291; VCTN1; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1; vtcn1 {ECO:0000312
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ

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Fischer Scientific

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Antigen:
CD253 (TRAIL)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P50592
Gene Symbols:
TNFSF10
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22035
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization
Clone:
N2B2
Conjugate:
Unconjugated
Gene:
TNFSF10
Gene Alias:
A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ

Img

Fischer Scientific

50-133-52

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Antigen:
CD253 (TRAIL)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P50592
Gene Symbols:
TNFSF10
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22035
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization
Clone:
N2B2
Conjugate:
Unconjugated
Gene:
TNFSF10
Gene Alias:
A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
Host Species:
Rat
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ

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Invitrogen

50-133-54

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Antigen:
CD254 (RANK Ligand)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
O35235
Gene Symbols:
TNFSF11
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21943
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay
Clone:
IK22/5
Conjugate:
Unconjugated
Gene:
TNFSF11
Gene Alias:
CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ