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7105417

PLGF Antibody (PLGF/94), Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

PLGF

Dilution

Western Blot 1-2ug/ml, SDS-Page

Classification

Monoclonal

Form

Purified

Regulatory Status

RUO

Target Species

Human

Gene Accession No.

P49763

Gene ID (Entrez)

5228

Immunogen

Recombinant human PLGF protein

Primary or Secondary

Primary

Content And Storage

Store at 4C.

Molecular Weight of Antigen

18 kDa

Clone

PLGF/94

Applications

Western Blot, SDS-Page

Conjugate

Unconjugated

Host Species

Mouse

Research Discipline

Angiogenesis

Formulation

PBS with 0.05% BSA. with 0.05% Sodium Azide

Gene Alias

D12S1900, PGFL, placenta growth factor, placental growth factor, placental growth factor, vascular endothelial growth factor-related protein, PlGF, PlGF-2, PLGFplacental growth factor-like, SHGC-10760

Gene Symbols

PGF

Isotype

IgG1 κ

Purification Method

Protein A purified

Test Specificity

The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

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Description

PLGF Monoclonal specifically detects PLGF in Human samples
It is validated for ELISA, Functional.

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Show Difference

Fischer Scientific

Mouse Monoclonal Antibody...

Antigen:

PLGF

Dilution:

Western Blot 1-2ug/ml, SDS-Page

Classification:

Monoclonal

Form:

Purified

Regulatory Status:

RUO

Target Species:

Human

Gene Accession No.:

P49763

Gene ID (Entrez):

5228

Immunogen:

Recombinant human PLGF protein

Primary or Secondary:

Primary

Content And Storage:

Store at 4C.

Molecular Weight of Antigen:

18 kDa

Clone:

PLGF/94

Applications:

Western Blot, SDS-Page

Conjugate:

Unconjugated

Host Species:

Mouse

Research Discipline:

Angiogenesis

Formulation:

PBS with 0.05% BSA. with 0.05% Sodium Azide

Gene Alias:

D12S1900, PGFL, placenta growth factor, placental growth factor, placental growth factor, vascular endothelial growth factor-related protein, PlGF, PlGF-2, PLGFplacental growth factor-like, SHGC-10760

Gene Symbols:

PGF

Isotype:

IgG1 κ

Purification Method:

Protein A purified

Test Specificity:

The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

Fischer Scientific

Mouse Monoclonal Antibody...

Antigen:

Prolactin R

Dilution:

Western Blot 0.25-0.5ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunohistochemistry-Paraffin 0.5-1.0ug/ml

Classification:

Monoclonal

Form:

Purified

Regulatory Status:

RUO

Target Species:

Human

Gene Accession No.:

P16471

Gene ID (Entrez):

5618

Immunogen:

Semi-purified human prolactin receptor

Primary or Secondary:

Primary

Content And Storage:

Store at 4C.

Molecular Weight of Antigen:

70 kDa

Clone:

SPM213

Applications:

Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)

Conjugate:

Unconjugated

Host Species:

Mouse

Research Discipline:

Apoptosis

Formulation:

PBS with 0.05% BSA. with 0.05% Sodium Azide

Gene Alias:

delta 4-delta 7/11 truncated prolactin receptor, delta 4-SF1b truncated prolactin receptor, hPRL receptor, hPRLrI, PRL-R, prolactin receptor, prolactin receptor delta 7/11, secreted prolactin binding protein

Gene Symbols:

PRLR

Isotype:

IgG1 κ

Purification Method:

Protein A purified

Test Specificity:

It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.

Fischer Scientific

Mouse Monoclonal Antibody...

Antigen:

Prolactin R

Dilution:

Western Blot 0.25-0.5ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunohistochemistry-Paraffin 0.5-1.0ug/ml

Classification:

Monoclonal

Form:

Purified

Regulatory Status:

RUO

Target Species:

Human

Gene Accession No.:

P16471

Gene ID (Entrez):

5618

Immunogen:

Semi-purified human prolactin receptor

Primary or Secondary:

Primary

Content And Storage:

Store at 4C.

Molecular Weight of Antigen:

70 kDa

Clone:

SPM213

Applications:

Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)

Conjugate:

Unconjugated

Host Species:

Mouse

Research Discipline:

Apoptosis

Formulation:

PBS with 0.05% BSA. with 0.05% Sodium Azide

Gene Alias:

delta 4-delta 7/11 truncated prolactin receptor, delta 4-SF1b truncated prolactin receptor, hPRL receptor, hPRLrI, PRL-R, prolactin receptor, prolactin receptor delta 7/11, secreted prolactin binding protein

Gene Symbols:

PRLR

Isotype:

IgG1 κ

Purification Method:

Protein A purified

Test Specificity:

It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.

Fischer Scientific

Mouse Monoclonal Antibody...

Antigen:

TFF1/pS2

Dilution:

Western Blot 0.5-1.0ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen 0.5-1.0ug/ml

Classification:

Monoclonal

Form:

Purified

Regulatory Status:

RUO

Target Species:

Human, Primate

Gene Accession No.:

P04155

Gene ID (Entrez):

7031

Immunogen:

Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.

Primary or Secondary:

Primary

Content And Storage:

Store at 4C.

Molecular Weight of Antigen:

6.5 kDa

Clone:

SPM573

Applications:

Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)

Conjugate:

Unconjugated

Host Species:

Mouse

Research Discipline:

Breast Cancer, Cancer

Formulation:

PBS with 0.05% BSA. with 0.05% Sodium Azide

Gene Alias:

BCEIbreast cancer, estrogen-inducible sequence expressed in, Breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, D21S21, gastrointestinal trefoil protein pS2, hP1.A, HPS2, pNR-2, Polypeptide P1.A, Protein pS2, pS2, trefoil factor 1, trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A

Gene Symbols:

TFF1

Isotype:

IgG1 κ

Purification Method:

Protein A purified

Test Specificity:

It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of re