7121225
Bcl-6 Mouse anti-Human, Clone: BCL6/1475, Novus Biologicals™
Mouse Monoclonal Antibody has been used in 1 publication
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
Bcl-6
Concentration
0.2 mg/mL
Applications
Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, SDS-Page
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation
10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez)
604
Immunogen
Recombinant human bcl-6 protein fragment (aa256-389)
Primary or Secondary
Primary
Content And Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen
95 kDa
Clone
BCL6/1475
Dilution
Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Human
Gene Alias
B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols
BCL6
Isotype
IgG1 κ
Purification Method
Protein A or G purified
Test Specificity
The specificity of this monoclonal antibody to its intended target was validated by HuProt(TM) Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma
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Description
- Bcl-6 Monoclonal specifically detects Bcl-6 in Human samples
- It is validated for Western Blot, Flow Cytometry, Protein Array.
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Antigen: Bcl-6
Concentration: 0.2 mg/mL
Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, SDS-Page
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation: 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez): 604
Immunogen: Recombinant human bcl-6 protein fragment (aa256-389)
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen: 95 kDa
Clone: BCL6/1475
Dilution: Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols: BCL6
Isotype: IgG1 κ
Purification Method: Protein A or G purified
Test Specificity: The specificity of this monoclonal antibody to its intended target was validated by HuProt(TM) Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma
Antigen:
Bcl-6
Concentration:
0.2 mg/mL
Applications:
Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, SDS-Page
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation:
10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez):
604
Immunogen:
Recombinant human bcl-6 protein fragment (aa256-389)
Primary or Secondary:
Primary
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen:
95 kDa
Clone:
BCL6/1475
Dilution:
Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols:
BCL6
Isotype:
IgG1 κ
Purification Method:
Protein A or G purified
Test Specificity:
The specificity of this monoclonal antibody to its intended target was validated by HuProt(TM) Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma
Antigen: Bcl-6
Concentration: 0.2 mg/mL
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation: 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez): 604
Immunogen: Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen: 95 kDa
Clone: BCL6/1527
Dilution: Flow Cytometry 0.5-1 ug/million cells, Immunohistochemistry-Paraffin 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols: BCL6
Isotype: IgG1 κ
Purification Method: Protein A or G purified
Test Specificity: The specificity of this monoclonal antibody to its intended target was validated by HuProt Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Antigen:
Bcl-6
Concentration:
0.2 mg/mL
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation:
10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez):
604
Immunogen:
Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
Primary or Secondary:
Primary
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen:
95 kDa
Clone:
BCL6/1527
Dilution:
Flow Cytometry 0.5-1 ug/million cells, Immunohistochemistry-Paraffin 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols:
BCL6
Isotype:
IgG1 κ
Purification Method:
Protein A or G purified
Test Specificity:
The specificity of this monoclonal antibody to its intended target was validated by HuProt Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Antigen: Bcl-6
Concentration: 0.2 mg/mL
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation: 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez): 604
Immunogen: Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen: 95 kDa
Clone: BCL6/1527
Dilution: Flow Cytometry 0.5-1 ug/million cells, Immunohistochemistry-Paraffin 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols: BCL6
Isotype: IgG1 κ
Purification Method: Protein A or G purified
Test Specificity: The specificity of this monoclonal antibody to its intended target was validated by HuProt Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Antigen:
Bcl-6
Concentration:
0.2 mg/mL
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cancer, Cell Cycle and Replication, Tumor Suppressors
Formulation:
10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez):
604
Immunogen:
Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
Primary or Secondary:
Primary
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen:
95 kDa
Clone:
BCL6/1527
Dilution:
Flow Cytometry 0.5-1 ug/million cells, Immunohistochemistry-Paraffin 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols:
BCL6
Isotype:
IgG1 κ
Purification Method:
Protein A or G purified
Test Specificity:
The specificity of this monoclonal antibody to its intended target was validated by HuProt Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Antigen: Enolase 2/Neuron-specific Enolase
Concentration: 0.2 mg/mL
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), SDS-Page
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cancer, Cellular Markers, Neuronal Cell Markers, Neuroscience
Formulation: 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez): 2026
Immunogen: A synthetic peptide of human NSE gamma (around aa416-433; exact sequence is proprietary)
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen: 50 kDa
Clone: ENO2/1462
Dilution: Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, Immunohistochemistry-Paraffin 0.1-0.2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: 2-phospho-D-glycerate hydrolyase, 2-phospho-D-glycerate hydro-lyase, EC 4.2.1.11, Enolase 2, enolase 2 (gamma, neuronal), gamma-enolase, Neural enolase, neuron specific gamma enolase, neurone-specific enolase, Neuron-specific enolase, NSE
Gene Symbols: ENO2
Isotype: IgG2b
Purification Method: Protein A or G purified
Test Specificity: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of about 50kDa, which is identified as gamma -enolase. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.
Antigen:
Enolase 2/Neuron-specific Enolase
Concentration:
0.2 mg/mL
Applications:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), SDS-Page
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cancer, Cellular Markers, Neuronal Cell Markers, Neuroscience
Formulation:
10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez):
2026
Immunogen:
A synthetic peptide of human NSE gamma (around aa416-433; exact sequence is proprietary)
Primary or Secondary:
Primary
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Molecular Weight of Antigen:
50 kDa
Clone:
ENO2/1462
Dilution:
Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, Immunohistochemistry-Paraffin 0.1-0.2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
2-phospho-D-glycerate hydrolyase, 2-phospho-D-glycerate hydro-lyase, EC 4.2.1.11, Enolase 2, enolase 2 (gamma, neuronal), gamma-enolase, Neural enolase, neuron specific gamma enolase, neurone-specific enolase, Neuron-specific enolase, NSE
Gene Symbols:
ENO2
Isotype:
IgG2b
Purification Method:
Protein A or G purified
Test Specificity:
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of about 50kDa, which is identified as gamma -enolase. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.