7121499
MAML3 Mouse anti-Human, Clone-MAML3/1303, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
MAML3
Concentration
1 mg/mL
Applications
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human
Gene Alias
CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3
Gene Symbols
MAML3
Isotype
IgG1
Purification Method
Protein A or G purified
Test Specificity
MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Clone
MAML3/1303
Dilution
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 0.5 - 1 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Neuroscience
Formulation
PBS with No Preservative
Gene ID (Entrez)
55534
Immunogen
Recombinant human MAML3 protein fragment
Primary or Secondary
Primary
Content And Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Molecular Weight of Antigen
160 kDa
Related Products
Description
- MAML3 Monoclonal specifically detects MAML3 in Human samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: MAML3
Concentration: 1 mg/mL
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3
Gene Symbols: MAML3
Isotype: IgG1
Purification Method: Protein A or G purified
Test Specificity: MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Clone: MAML3/1303
Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 0.5 - 1 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Neuroscience
Formulation: PBS with No Preservative
Gene ID (Entrez): 55534
Immunogen: Recombinant human MAML3 protein fragment
Primary or Secondary: Primary
Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
Molecular Weight of Antigen: 160 kDa
Antigen:
MAML3
Concentration:
1 mg/mL
Applications:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3
Gene Symbols:
MAML3
Isotype:
IgG1
Purification Method:
Protein A or G purified
Test Specificity:
MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Clone:
MAML3/1303
Dilution:
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 0.5 - 1 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Neuroscience
Formulation:
PBS with No Preservative
Gene ID (Entrez):
55534
Immunogen:
Recombinant human MAML3 protein fragment
Primary or Secondary:
Primary
Content And Storage:
Store at -20 to -80C. Avoid freeze-thaw cycles.
Molecular Weight of Antigen:
160 kDa
Antigen: Lymphotoxin beta R/TNFRSF3
Concentration: __
Applications: __
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: CD18, D12S370, ltbetar, LT-BETA-R, LTBR, lymphotoxin B receptor, lymphotoxin beta receptor (TNFR superfamily, member 3), Lymphotoxin-beta receptor, LymphotoxinbR, TNF RIII, TNF Rrp, TNFCRTNF-RIII, TNFR superfamily, member 3, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3, TNFRSF3TNFR-III, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, tumor necrosis factor receptor superfamily member 3, tumor necrosis factor receptor superfamily, member 3, Tumor necrosis factor receptor type III
Gene Symbols: __
Isotype: IgG1
Purification Method: Protein A or G purified from hybridoma culture supernatant
Test Specificity: Detects human Lymphotoxin beta R/TNFRSF3 in direct ELISAs.
Clone: 71315
Dilution: Agonist Activity 1.5-9 ng/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Agonist Activity
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene ID (Entrez): 4055
Immunogen: Mouse myeloma cell line NS0-derived recombinant human Lymphotoxin beta R/TNFRSF3 Gln31-Met227 Accession # P36941
Primary or Secondary: Primary
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Molecular Weight of Antigen: __
Antigen:
Lymphotoxin beta R/TNFRSF3
Concentration:
__
Applications:
__
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
CD18, D12S370, ltbetar, LT-BETA-R, LTBR, lymphotoxin B receptor, lymphotoxin beta receptor (TNFR superfamily, member 3), Lymphotoxin-beta receptor, LymphotoxinbR, TNF RIII, TNF Rrp, TNFCRTNF-RIII, TNFR superfamily, member 3, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3, TNFRSF3TNFR-III, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, tumor necrosis factor receptor superfamily member 3, tumor necrosis factor receptor superfamily, member 3, Tumor necrosis factor receptor type III
Gene Symbols:
__
Isotype:
IgG1
Purification Method:
Protein A or G purified from hybridoma culture supernatant
Test Specificity:
Detects human Lymphotoxin beta R/TNFRSF3 in direct ELISAs.
Clone:
71315
Dilution:
Agonist Activity 1.5-9 ng/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Agonist Activity
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene ID (Entrez):
4055
Immunogen:
Mouse myeloma cell line NS0-derived recombinant human Lymphotoxin beta R/TNFRSF3 Gln31-Met227 Accession # P36941
Primary or Secondary:
Primary
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Molecular Weight of Antigen:
__
Antigen: Lgr5/GPR49
Concentration: __
Applications: Flow Cytometry
Conjugate: R-PE
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: FEX, G protein-coupled receptor 49, GPR49, GPR49G-protein coupled receptor HG38, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, GRP49, HG38, leucine-rich repeat containing G protein-coupled receptor 5, leucine-rich repeat-containing G protein-coupled receptor 5, leucine-rich repeat-containing G-protein coupled receptor 5, MGC117008, orphan G protein-coupled receptor HG38
Gene Symbols: __
Isotype: IgG2b
Purification Method: Protein A or G purified from hybridoma culture supernatant
Test Specificity: Detects mouse Lgr5/GPR49 in direct ELISAs. Stains mouse Lgr5 transfected cells but not irrelevant transfectants in Flow Cytometry.
Clone: 889901
Dilution: Flow Cytometry 0.1 ug/10^6 cells
Classification: Monoclonal
Host Species: Rat
Research Discipline: __
Formulation: Supplied in a saline solution containing BSA and Sodium Azide.
Gene ID (Entrez): 8549
Immunogen: Mouse Lgr5/GPR49 N-terminal peptide Ala21-Cys34 Accession # Q9Z1P4
Primary or Secondary: Primary
Content And Storage: Protect from light.Do not freeze.12 months from date of receipt, 2 to 8 degreesC as supplied.
Molecular Weight of Antigen: __
Antigen:
Lgr5/GPR49
Concentration:
__
Applications:
Flow Cytometry
Conjugate:
R-PE
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
FEX, G protein-coupled receptor 49, GPR49, GPR49G-protein coupled receptor HG38, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, GRP49, HG38, leucine-rich repeat containing G protein-coupled receptor 5, leucine-rich repeat-containing G protein-coupled receptor 5, leucine-rich repeat-containing G-protein coupled receptor 5, MGC117008, orphan G protein-coupled receptor HG38
Gene Symbols:
__
Isotype:
IgG2b
Purification Method:
Protein A or G purified from hybridoma culture supernatant
Test Specificity:
Detects mouse Lgr5/GPR49 in direct ELISAs. Stains mouse Lgr5 transfected cells but not irrelevant transfectants in Flow Cytometry.
Clone:
889901
Dilution:
Flow Cytometry 0.1 ug/10^6 cells
Classification:
Monoclonal
Host Species:
Rat
Research Discipline:
__
Formulation:
Supplied in a saline solution containing BSA and Sodium Azide.
Gene ID (Entrez):
8549
Immunogen:
Mouse Lgr5/GPR49 N-terminal peptide Ala21-Cys34 Accession # Q9Z1P4
Primary or Secondary:
Primary
Content And Storage:
Protect from light.Do not freeze.12 months from date of receipt, 2 to 8 degreesC as supplied.
Molecular Weight of Antigen:
__
Antigen: Lactate Dehydrogenase B
Concentration: __
Applications: Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry, KnockDown
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: EC 1.1.1, EC 1.1.1.27, Epididymis Secretory Protein Li 281, HEL-S-281, lactate dehydrogenase B, LDH heart subunit, LDHB, LDH-B, LDHBD, LDH-H, L-lactate dehydrogenase B chain, Renal Carcinoma Antigen NY-REN-46, TRG-5
Gene Symbols: __
Isotype: IgG
Purification Method: Protein A or G purified from cell culture supernatant
Test Specificity: Detects human LDHB in direct ELISAs and Western blots.
Clone: 2057D
Dilution: Western Blot 0.05 ug/mL, Immunohistochemistry 1-25 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 3-25 ug/mL, Knockout Validated
Classification: Monoclonal
Host Species: Rabbit
Research Discipline: __
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Gene ID (Entrez): 3945
Immunogen: E. coli-derived recombinant human LDHB Met1-Val93 Accession # P07195
Primary or Secondary: Primary
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Molecular Weight of Antigen: __
Antigen:
Lactate Dehydrogenase B
Concentration:
__
Applications:
Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry, KnockDown
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
EC 1.1.1, EC 1.1.1.27, Epididymis Secretory Protein Li 281, HEL-S-281, lactate dehydrogenase B, LDH heart subunit, LDHB, LDH-B, LDHBD, LDH-H, L-lactate dehydrogenase B chain, Renal Carcinoma Antigen NY-REN-46, TRG-5
Gene Symbols:
__
Isotype:
IgG
Purification Method:
Protein A or G purified from cell culture supernatant
Test Specificity:
Detects human LDHB in direct ELISAs and Western blots.
Clone:
2057D
Dilution:
Western Blot 0.05 ug/mL, Immunohistochemistry 1-25 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 3-25 ug/mL, Knockout Validated
Classification:
Monoclonal
Host Species:
Rabbit
Research Discipline:
__
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Gene ID (Entrez):
3945
Immunogen:
E. coli-derived recombinant human LDHB Met1-Val93 Accession # P07195
Primary or Secondary:
Primary
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Molecular Weight of Antigen:
__