Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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PTH
1 mg/mL
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Unconjugated
RUO
Human
Parathormone, Parathyrin, parathyroid hormone, parathyroid hormone 1, PTH1
PTH
IgG2b κ
Protein A or G purified
Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
SPM604
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 0.5 - 1 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Monoclonal
Mouse
Apoptosis, Biologically Active Proteins, Cancer
PBS with No Preservative
5741
A synthetic peptide from the N-terminal of human PTH polypeptide.
Primary
Store at -20 to -80C. Avoid freeze-thaw cycles.
9 kDa