7162886
Aquaporin 4, Rabbit anti-Rat, Mouse, Human, Polyclonal, Millipore Sigma™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Aquaporin 4
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Rat, Mouse, Human
Gene Alias
AQP-4;Mercurial-insensitive water channel;MIWC
Gene Symbols
Aqp4
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen
∽34.0 kDa observed; 34.48 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution
Immunohistochemistry (Paraffin) Analysis : A 1:1,000 dilution from a representative lot detected Aquaporin 4 in rat cerebral cortex tissue.Western Blotting Analysis: A 1:500 dilution from a representative lot detected Aquaporin 4 in human brain tissue lysate.
Classification
Polyclonal
Host Species
Rabbit
Research Discipline
Neuroscience
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine, 150 mM NaCl (pH 7.4) with 0.05% sodium azide.
Gene ID (Entrez)
NP_001257487.1
Immunogen
GST/HIs-taged recombinant fragment corresponding to 75 amino acids from the C-terminal region of rat Aquaporin-4.
Purification Method
Affinity Purified
Test Specificity
This rabbit polyclonal antiody detects Aquaporin-4. It targets an epitope with in 75 amino acids from the C-terminal.
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Description
- Anti-Aquaporin 4, Cat
- No
- ABN910, is a highly specific rabbit polyclonal antibody that targets Aquaporin 4 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Aquaporin-4 (UniProt: P47863; also known as AQP-4, Mercurial-insensitive water channel, MIWC) is encoded by the Aqp4 gene (Gene ID: 25293) in rat
- Aquaporin-4 is a multi-pass membrane homotetrameric protein that forms a water-specific channel and serves as an osmoreceptor that regulates body water balance and mediates water flow within the central nervous system
- Its extracellular domains are localized to amino acids 58-64, 137-155, and 206-231); its transmembrane domains are in amino acids 37-57, 65-85, 116-136, 156-176, 185-205, and 232-252); and the cytoplasmic domain is in amino acids 1-36, 86-115, 177-184, and 253-323)
- Aquaporin-4 is largely expressed in the brain and the skeletal muscle and at lower levels in heart, kidney, and lung tissue
- Phosphorylation of Aquaporin-4 at Serine 180 by protein kinase C is shown to reduce conductance by about 50%, whereas phosphorylation at Serine 111 by protein kinase G in response to glutamate can increase conductance by about 40%
- Two isoforms of Aquaporin-4 have been described that are produced by alternative splicing
- Antibodies to Aquaporin-4 can serve as useful serum markers to distinguishing neuromyelitis optica (NM) from multiple sclerosis
- Clone mCCD does not cause redistribution of Aquaporin-4 and also it does not affect coaggregation astrocytic CD32-B and Aquaporin-4
- (Ref.: Hinson, SR et al
- (2017)
- Proc
- Natl
- Acad
- Sci
- USA 114(21); 5491-5496).
Compare Similar Items
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Antigen: Aquaporin 4
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Rat, Mouse, Human
Gene Alias: AQP-4;Mercurial-insensitive water channel;MIWC
Gene Symbols: Aqp4
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽34.0 kDa observed; 34.48 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: Immunohistochemistry (Paraffin) Analysis : A 1:1,000 dilution from a representative lot detected Aquaporin 4 in rat cerebral cortex tissue.Western Blotting Analysis: A 1:500 dilution from a representative lot detected Aquaporin 4 in human brain tissue lysate.
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Neuroscience
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine, 150 mM NaCl (pH 7.4) with 0.05% sodium azide.
Gene ID (Entrez): NP_001257487.1
Immunogen: GST/HIs-taged recombinant fragment corresponding to 75 amino acids from the C-terminal region of rat Aquaporin-4.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antiody detects Aquaporin-4. It targets an epitope with in 75 amino acids from the C-terminal.
Antigen:
Aquaporin 4
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Rat, Mouse, Human
Gene Alias:
AQP-4;Mercurial-insensitive water channel;MIWC
Gene Symbols:
Aqp4
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽34.0 kDa observed; 34.48 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
Immunohistochemistry (Paraffin) Analysis : A 1:1,000 dilution from a representative lot detected Aquaporin 4 in rat cerebral cortex tissue.Western Blotting Analysis: A 1:500 dilution from a representative lot detected Aquaporin 4 in human brain tissue lysate.
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Neuroscience
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine, 150 mM NaCl (pH 7.4) with 0.05% sodium azide.
Gene ID (Entrez):
NP_001257487.1
Immunogen:
GST/HIs-taged recombinant fragment corresponding to 75 amino acids from the C-terminal region of rat Aquaporin-4.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antiody detects Aquaporin-4. It targets an epitope with in 75 amino acids from the C-terminal.
Antigen: P2Y12 Receptor
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Rat, Human
Gene Alias: P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Gene Symbols: P2RY12;HORK3
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_073625
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
P2Y12 Receptor
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Rat, Human
Gene Alias:
P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Gene Symbols:
P2RY12;HORK3
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_073625
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen: Frizzled-2
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: Fz-2;hFz2;FzE2
Gene Symbols: FZD2
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: __
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): __
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
Frizzled-2
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Fz-2;hFz2;FzE2
Gene Symbols:
FZD2
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
__
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
__
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen: Frizzled-2
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: Fz-2;hFz2;FzE2
Gene Symbols: FZD2
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: __
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): __
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
Frizzled-2
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Fz-2;hFz2;FzE2
Gene Symbols:
FZD2
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
__
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
__
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.