7162887
P2Y12 Receptor, Rabbit anti-Rat, Human, Polyclonal, Millipore Sigma™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
P2Y12 Receptor
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Rat, Human
Gene Alias
P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Gene Symbols
P2RY12;HORK3
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen
∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution
Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Classification
Polyclonal
Host Species
Rabbit
Research Discipline
Signaling
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NP_073625
Immunogen
KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method
Affinity Purified
Test Specificity
This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
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Description
- Anti-P2Y12 Receptor, Cat
- No
- ABS1487, is a rabbit polyclonal antibody that detects P2Y purinoceptor 12 and has been tested for Immunohistochemistry (Paraffin) and Western Blotting
- P2Y purinoceptor 12 (UniProt: Q9H244; also known as P2Y12, ADP-glucose receptor, ADPG-R, P2T(AC), P2Y(AC), P2Y(cyc), P2Y12 platelet ADP receptor, P2Y(ADP), SP1999) is encoded by the P2RY12 (also known as HORK3) gene (Gene ID: 64805) in human
- P2Y12 is a multi-pass metabotropic receptor that is highly expressed in the platelets
- Lower expression levels have been observed in the brain, lung, and adrenal glands
- P2Y12 serves as a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system
- It is not activated by UDP and UTP
- It is required for normal platelet aggregation and blood coagulation
- It is the predominant receptor involved in the ADP-stimulated activation of the glycoprotein IIb/IIIa receptor
- Activation of the glycoprotein IIb/IIIa receptor results in enhanced platelet degranulation and thromboxane production, and prolonged platelet aggregation
- P2Y12 receptor has also been reported to be expressed on microglia and is required to neuropathic pain following peripheral nerve injury
- P2Y12 has seven transmembrane, four cytoplasmic, and four extracellular domains
- The transmembrane helices are somewhat tilted and/or kinked
- Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices
- Mutations in P2RY12 gene have been linked to bleeding disorders resulting from severe impairment of platelet response to ADP resulting in defective platelet aggregation
- (Ref.: Burnstock G
- (2009)
- Curr
- Pharm
- Des
- 15(15);1717-35; Damman, P., et al
- (2012)
- J
- Thromb
- Thrombolysis
- 33(2); 143-153).
Compare Similar Items
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Antigen: P2Y12 Receptor
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Rat, Human
Gene Alias: P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Gene Symbols: P2RY12;HORK3
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_073625
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
P2Y12 Receptor
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Rat, Human
Gene Alias:
P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Gene Symbols:
P2RY12;HORK3
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_073625
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen: Frizzled-2
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: Fz-2;hFz2;FzE2
Gene Symbols: FZD2
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: __
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): __
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
Frizzled-2
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Fz-2;hFz2;FzE2
Gene Symbols:
FZD2
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
__
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
__
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen: Frizzled-2
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: Fz-2;hFz2;FzE2
Gene Symbols: FZD2
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution: __
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): __
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
Frizzled-2
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Fz-2;hFz2;FzE2
Gene Symbols:
FZD2
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Dilution:
__
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
__
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen: FtsZ (GTPase)
Applications: Immunofluorescence, Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Bacteria
Gene Alias: Cell division protein FtsZ;Cell Division FtsZ GTPase
Gene Symbols: FtsZ;BSU15290
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Molecular Weight of Antigen: __
Dilution: Western Blotting Analysis: A representative lot detected FtsZ (GTPase) in Western Blotting applications (Lucet, I., et. al. (2000). EMBO J. 19(7):1467-75; Bisson-Filho, A.W., et. al. (2017). Science. 355(6326):739-743).Immunofluorescence Analysis: A representative lot detected FtsZ (GTPase) in Immunofluorescence applications (Daniel, R.A., et. al. (2000). Mol Microbiol. 35(2):299-311).
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene ID (Entrez): NP_389412
Immunogen: Full length purified FtsZ from Bacillus subtilis.
Purification Method: Unpurified
Test Specificity: This rabbit polyclonal antibody detects Cell Division Protein FTsZ in Bacillus subtilis.
Antigen:
FtsZ (GTPase)
Applications:
Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Bacteria
Gene Alias:
Cell division protein FtsZ;Cell Division FtsZ GTPase
Gene Symbols:
FtsZ;BSU15290
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Molecular Weight of Antigen:
__
Dilution:
Western Blotting Analysis: A representative lot detected FtsZ (GTPase) in Western Blotting applications (Lucet, I., et. al. (2000). EMBO J. 19(7):1467-75; Bisson-Filho, A.W., et. al. (2017). Science. 355(6326):739-743).Immunofluorescence Analysis: A representative lot detected FtsZ (GTPase) in Immunofluorescence applications (Daniel, R.A., et. al. (2000). Mol Microbiol. 35(2):299-311).
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene ID (Entrez):
NP_389412
Immunogen:
Full length purified FtsZ from Bacillus subtilis.
Purification Method:
Unpurified
Test Specificity:
This rabbit polyclonal antibody detects Cell Division Protein FTsZ in Bacillus subtilis.