7162888
Frizzled-2, Rabbit anti-Human, Polyclonal, Millipore Sigma™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Frizzled-2
Classification
Polyclonal
Host Species
Rabbit
Research Discipline
Signaling
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
FZD2
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human
Gene Alias
Fz-2;hFz2;FzE2
Immunogen
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method
Affinity Purified
Test Specificity
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
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Description
- Detects Frizzled-2 using this rabbit polyclonal Anti-Frizzled-2 Antibody, Cat
- No
- ABS1491, tested for use in Western Blotting
- Frizzled-2 (UniProt: Q14332; also known as Fz-2, hFz2, FzE2) is encoded by the FZD2 gene (Gene ID: 2535) in human
- Frizzled-2 is a multi-pass membrane protein that is widely expressed in adult tissues
- In fetus, higher levels are expressed in the brain, lung, and kidney and lower levels are observed in liver
- Frizzled serves as a receptor for Wnt proteins
- Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes
- In the presence of Wnt the Frizzled receptor is activated, which along with low-density lipoprotein receptor-related proteins (LRP) 5 and 6 stabilizes beta-catenin
- The formation of Wnt-Frizzled-LRP6 complex, together with the recruitment of the scaffolding protein Dishevelled (Dvl), results in LRP6 phosphorylation and activation and the recruitment of the Axin complex to the receptors
- This leads to the inhibition of Axin-mediated beta-catenin phosphorylation, which stabilizes beta-catenin
- Frizzled-2 is synthesized with a signal peptide (aa 1-23), which is subsequently cleaved off in the mature form
- Its Fz domain is localized to amino acids 34-153 and this domain is involved in its binding with Wnt ligands
- Frizzled-2 can be ubiquitinated by RING-type E3 ubiquitin transferase ZNRF3 leading to its proteasomal degradation
- Abnormalities in Wnt signaling are reported to promote birth defects, degenerative diseases, and cancer.
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Antigen: Frizzled-2
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: FZD2
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Gene Alias: Fz-2;hFz2;FzE2
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen:
Frizzled-2
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
FZD2
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Fz-2;hFz2;FzE2
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Antigen: FtsZ (GTPase)
Classification: Polyclonal
Host Species: Rabbit
Research Discipline: Signaling
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols: FtsZ;BSU15290
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Molecular Weight of Antigen: __
Applications: Immunofluorescence, Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Bacteria
Gene Alias: Cell division protein FtsZ;Cell Division FtsZ GTPase
Immunogen: Full length purified FtsZ from Bacillus subtilis.
Purification Method: Unpurified
Test Specificity: This rabbit polyclonal antibody detects Cell Division Protein FTsZ in Bacillus subtilis.
Antigen:
FtsZ (GTPase)
Classification:
Polyclonal
Host Species:
Rabbit
Research Discipline:
Signaling
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols:
FtsZ;BSU15290
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Molecular Weight of Antigen:
__
Applications:
Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Bacteria
Gene Alias:
Cell division protein FtsZ;Cell Division FtsZ GTPase
Immunogen:
Full length purified FtsZ from Bacillus subtilis.
Purification Method:
Unpurified
Test Specificity:
This rabbit polyclonal antibody detects Cell Division Protein FTsZ in Bacillus subtilis.
Antigen: CD34
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: CD34
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Molecular Weight of Antigen: 40.72 kDa Calculated. This antibody recognizes a heavily glycosylated transmembrane protein: gp 105-120 kDa.
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Monkey, Human
Gene Alias: Hematopoietic progenitor cell antigen CD34
Immunogen: Human placental endothelial membrane vesicles.
Purification Method: Protein G purified
Test Specificity: Clone QBEnd/10 specifically detects CD34 in human and non-human primates.
Antigen:
CD34
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
CD34
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Molecular Weight of Antigen:
40.72 kDa Calculated. This antibody recognizes a heavily glycosylated transmembrane protein: gp 105-120 kDa.
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Monkey, Human
Gene Alias:
Hematopoietic progenitor cell antigen CD34
Immunogen:
Human placental endothelial membrane vesicles.
Purification Method:
Protein G purified
Test Specificity:
Clone QBEnd/10 specifically detects CD34 in human and non-human primates.
Antigen: BASE-tag
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Cap
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen: __
Applications: __
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Virus
Gene Alias: Capsid protein VP1;Capsid protein AVV9
Immunogen: Empty Adeno-associated virus 9 (AAV9) Capsids
Purification Method: Protein G purified
Test Specificity: Clone 7C7 is a mouse monoclonal antibody that detects various serotypes of Adeno-associated virus (AVV). It targets an epitope with in 14 amino acids from the N-terminal region.
Antigen:
BASE-tag
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Cap
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Molecular Weight of Antigen:
__
Applications:
__
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Virus
Gene Alias:
Capsid protein VP1;Capsid protein AVV9
Immunogen:
Empty Adeno-associated virus 9 (AAV9) Capsids
Purification Method:
Protein G purified
Test Specificity:
Clone 7C7 is a mouse monoclonal antibody that detects various serotypes of Adeno-associated virus (AVV). It targets an epitope with in 14 amino acids from the N-terminal region.