7162891

BASE-tag, Mouse anti-Virus, Clone: 7C7, Millipore Sigma™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

BASE-tag

Classification

Monoclonal

Form

Purified

Regulatory Status

RUO

Target Species

Virus

Gene Alias

Capsid protein VP1;Capsid protein AVV9

Immunogen

Empty Adeno-associated virus 9 (AAV9) Capsids

Primary or Secondary

Primary

Content And Storage

Stable for 1 year at 2-8°C from date of receipt.

Clone

7C7

Conjugate

Unconjugated

Host Species

Mouse

Research Discipline

Inflammation & Immunology

Formulation

Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols

Cap

Isotype

IgG2b κ

Purification Method

Protein G purified

Test Specificity

Clone 7C7 is a mouse monoclonal antibody that detects various serotypes of Adeno-associated virus (AVV). It targets an epitope with in 14 amino acids from the N-terminal region.

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Description

  • Anti-BASE-tag, clone 7C7, Cat
  • No
  • MAB131884, is a mouse monoclonal antibody that recognizes the epitope QPAKKRLNFGQTGD and has been tested for use in Western Blotting, Immunoprecipitation, and Immunofluorescence
  • Capsid protein VP1 (UniProt: Q6JC40) is encoded by the Cap gene in Adeno-associated virus 9 (AAV9)
  • Adeno-associated viruses (AAV) are small non-enveloped DNA viruses that can serve as promising viral vectors for gene delivery, but can also elicits cellular and humoral immune responses
  • AAVs are reported to be nonpathogenic in humans and animals and display low immunogenicity
  • Following their attachment to cell surface receptor they are internalized via endocytosis and their intracellular trafficking is a rate-limiting, slow and inefficient process
  • AAVs contain an icosahedral capsid, which is 22 to 26 nm in diameter
  • They are shown to have a single-stranded DNA genome of approximately 4.7 kilobases that is flanked by two T-shaped inverted terminal repeats (ITRs)
  • The 7C7 an epitope-tag antibody recognizes a basic ten amino acid epitope (QPAKKRLNFGQTGD) with high specificity
  • The basic nature of the BASE-tag epitope sequence distinguishes it from other commonly used epitope tags, such as Myc, EQKLISEEDL, FLAG, DYKDDDDK, HA, YPYDVPDYA, V5 etc
  • Clone 7C7 recognizes capsid proteins VP1 and VP2, but not VP3
  • Based on sequence identity of the epitope sequence, this antibody is expected to recognize VP1 and VP2 of AAV serotypes 1,2,3,6,7,8, and 9
  • (Ref.: Nonnenmacher, M., and Weber, T (2012)
  • Gene Ther
  • 19(6); 649-658).

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Show Difference

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7162891

Mouse Monoclonal Antibody...


Antigen:
BASE-tag

Classification:
Monoclonal

Form:
Purified

Regulatory Status:
RUO

Target Species:
Virus

Gene Alias:
Capsid protein VP1;Capsid protein AVV9

Immunogen:
Empty Adeno-associated virus 9 (AAV9) Capsids

Primary or Secondary:
Primary

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.

Clone:
7C7

Conjugate:
Unconjugated

Host Species:
Mouse

Research Discipline:
Inflammation & Immunology

Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols:
Cap

Isotype:
IgG2b κ

Purification Method:
Protein G purified

Test Specificity:
Clone 7C7 is a mouse monoclonal antibody that detects various serotypes of Adeno-associated virus (AVV). It targets an epitope with in 14 amino acids from the N-terminal region.

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Mouse Monoclonal Antibody...


Antigen:
Reovirus Type 3 sigma 1 hemagglutinin

Classification:
Monoclonal

Form:
Purified

Regulatory Status:
RUO

Target Species:
Virus

Gene Alias:
T3 sigma 1;Reovirus T3 sigma 1

Immunogen:
Purified reovirus type 3 virons.

Primary or Secondary:
Primary

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.

Clone:
9BG5

Conjugate:
Unconjugated

Host Species:
Mouse

Research Discipline:
Inflammation & Immunology

Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols:
N/A

Isotype:
IgG2a κ

Purification Method:
Protein G purified

Test Specificity:
__

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Armenian Hamster Monoclonal Antibod...


Antigen:
PD-L1 B7-H1

Classification:
Monoclonal

Form:
Purified

Regulatory Status:
RUO

Target Species:
Mouse

Gene Alias:
Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274

Immunogen:
Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.

Primary or Secondary:
Primary

Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Clone:
10B5

Conjugate:
Unconjugated

Host Species:
Armenian Hamster

Research Discipline:
Apoptosis & Cancer

Formulation:
Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.

Gene Symbols:
Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1

Isotype:
__

Purification Method:
Protein G purified

Test Specificity:
This Armenian hamster monoclonal antibody detects Programmed cell death 1 ligand 1 (PD-L1) in murine species.

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Antigen:
PD-L1 B7-H1

Classification:
Monoclonal

Form:
Purified

Regulatory Status:
RUO

Target Species:
Mouse

Gene Alias:
Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274

Immunogen:
Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.

Primary or Secondary:
Primary

Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Clone:
10B5

Conjugate:
Unconjugated

Host Species:
Armenian Hamster

Research Discipline:
Apoptosis & Cancer

Formulation:
Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.

Gene Symbols:
Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1

Isotype:
__

Purification Method:
Protein G purified

Test Specificity:
This Armenian hamster monoclonal antibody detects Programmed cell death 1 ligand 1 (PD-L1) in murine species.