7162892
Reovirus Type 3 sigma 1 hemagglutinin, Mouse anti-Virus, Clone: 9BG5, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Reovirus Type 3 sigma 1 hemagglutinin
Dilution
Immunofluorescence Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Immunofluorescence applications (Barton, E.S., et. al. (2001). J Biol Chem. 276(3):2200-2211).Radioimmunoassay Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Radioimmunoassay applications (William, W.V., et. al. (1988). Proc Natl Acad Sci U S A. 85(17):6488-92). Flow Cytometry Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Flow Cytometry applications (Dietrich, M.H., et. al. (2017). J Virol. 91(4). pii: e01621-16).Neutralizing Analysis: A representative lot neutralized Reovirus Type 3 in Neutralizing applications (William, W.V., et. al. (1988). Proc Natl Acad Sci USA. 85(17):6488-92).
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Virus
Gene Alias
T3 sigma 1;Reovirus T3 sigma 1
Immunogen
Purified reovirus type 3 virons.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Clone
9BG5
Applications
Flow Cytometry, Immunofluorescence, Neutralization, Radioimmune Assays (RIA)
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Inflammation & Immunology
Formulation
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
N/A
Isotype
IgG2a κ
Purification Method
Protein G purified
Molecular Weight of Antigen
N/A
Related Products
Description
- Anti-Reovirus Type 3 sigma 1 hemagglutinin, clone 9BG5, Cat
- No
- MAB994-I, is a mouse monoclonal antibody that detects sigma 1 hemagglutinin of Reovirus type 3 and has been tested for use in Flow Cytometry, Radioimmunoassay, Immunofluorescence, and neutralizing applications
- Mammalian reoviruses are nonenveloped viruses with a segmented, double-stranded RNA genome
- Although these viruses can infect most mammalian species, they are usually asymptomatic in human
- In neonatal SCID NOD mice they can cause lethal infection
- Three major reovirus serotypes have been described that are differentiated by the capacity of antisera to neutralize viral infectivity and block hemagglutination
- Type 1 and 3 sigma 1 contain receptor-binding domains in both the tail and head regions and in type 3 sigma 1 tail is shown to bind alpha-linked sialic acid
- Sigma 1 is reported to engage glycan receptors and junctional adhesion molecule-A (JAM-A) and undergoes a conformational change during the proteolytic disassembly of virions to infectious subvirion particles (ISVPs) that accompany cell entry
- Type 3 reovirus is shown to spread to the central nervous system and causes lethal encephalitis in murine models
- Reovirus can also serve an oncolytic function and can hijack the activated Ras signaling pathway of host tumor cells
- It can induce apoptosis in tumor cells through both extrinsic and intrinsic pathways
- In this process viral uncoating is reported to be an essential factor
- Clone 9BG5 is shown to efficiently block HA by strain type 1 Lang (T1L) and ISVPs
- (Ref.: Yang WQ et al
- (2004)
- Clin
- Cancer Res
- 10(24); 8561-8576; Tyler, KL., et al
- (2004)
- J
- Infect
- Dis
- 189(9); 1664-1675; Dietrich, MH., et al
- (2017)
- J
- Virology 91(4); e01621-16).
Compare Similar Items
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Antigen: Reovirus Type 3 sigma 1 hemagglutinin
Dilution: Immunofluorescence Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Immunofluorescence applications (Barton, E.S., et. al. (2001). J Biol Chem. 276(3):2200-2211).Radioimmunoassay Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Radioimmunoassay applications (William, W.V., et. al. (1988). Proc Natl Acad Sci U S A. 85(17):6488-92). Flow Cytometry Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Flow Cytometry applications (Dietrich, M.H., et. al. (2017). J Virol. 91(4). pii: e01621-16).Neutralizing Analysis: A representative lot neutralized Reovirus Type 3 in Neutralizing applications (William, W.V., et. al. (1988). Proc Natl Acad Sci USA. 85(17):6488-92).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Virus
Gene Alias: T3 sigma 1;Reovirus T3 sigma 1
Immunogen: Purified reovirus type 3 virons.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: 9BG5
Applications: Flow Cytometry, Immunofluorescence, Neutralization, Radioimmune Assays (RIA)
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: N/A
Isotype: IgG2a κ
Purification Method: Protein G purified
Molecular Weight of Antigen: N/A
Antigen:
Reovirus Type 3 sigma 1 hemagglutinin
Dilution:
Immunofluorescence Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Immunofluorescence applications (Barton, E.S., et. al. (2001). J Biol Chem. 276(3):2200-2211).Radioimmunoassay Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Radioimmunoassay applications (William, W.V., et. al. (1988). Proc Natl Acad Sci U S A. 85(17):6488-92). Flow Cytometry Analysis: A representative lot detected Reovirus Type 3 sigma 1 hemagglutinin in Flow Cytometry applications (Dietrich, M.H., et. al. (2017). J Virol. 91(4). pii: e01621-16).Neutralizing Analysis: A representative lot neutralized Reovirus Type 3 in Neutralizing applications (William, W.V., et. al. (1988). Proc Natl Acad Sci USA. 85(17):6488-92).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Virus
Gene Alias:
T3 sigma 1;Reovirus T3 sigma 1
Immunogen:
Purified reovirus type 3 virons.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
9BG5
Applications:
Flow Cytometry, Immunofluorescence, Neutralization, Radioimmune Assays (RIA)
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
N/A
Isotype:
IgG2a κ
Purification Method:
Protein G purified
Molecular Weight of Antigen:
N/A
Antigen: PD-L1 B7-H1
Dilution: Inhibits Activity/Function Analysis: A representative lot blocked the activity of PD-L1 B7-H1 and inhibited apoptosis of activated alloreactive 2C T cells. (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Goldberg, M.V., et. al. (2007). Blood. 110(1):186-92; Joshi, T., et. al. (2009). PLoS Pathog. 5(5):e1000431; Liu, X., et. al. (2016). Sci Rep. 6:36722). Flow Cytometry Analysis: A representative lot detected PD-L1 B7-H1 in Flow Cytometry applications (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Dong, H., et. al. (2004). Immunity. 20(3):327-36).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274
Immunogen: Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone: 10B5
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Inhibition Assays
Conjugate: Unconjugated
Host Species: Armenian Hamster
Research Discipline: Apoptosis & Cancer
Formulation: Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.
Gene Symbols: Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1
Isotype: __
Purification Method: Protein G purified
Molecular Weight of Antigen: __
Antigen:
PD-L1 B7-H1
Dilution:
Inhibits Activity/Function Analysis: A representative lot blocked the activity of PD-L1 B7-H1 and inhibited apoptosis of activated alloreactive 2C T cells. (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Goldberg, M.V., et. al. (2007). Blood. 110(1):186-92; Joshi, T., et. al. (2009). PLoS Pathog. 5(5):e1000431; Liu, X., et. al. (2016). Sci Rep. 6:36722). Flow Cytometry Analysis: A representative lot detected PD-L1 B7-H1 in Flow Cytometry applications (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Dong, H., et. al. (2004). Immunity. 20(3):327-36).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274
Immunogen:
Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone:
10B5
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Inhibition Assays
Conjugate:
Unconjugated
Host Species:
Armenian Hamster
Research Discipline:
Apoptosis & Cancer
Formulation:
Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.
Gene Symbols:
Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1
Isotype:
__
Purification Method:
Protein G purified
Molecular Weight of Antigen:
__
Antigen: PD-L1 B7-H1
Dilution: Inhibits Activity/Function Analysis: A representative lot blocked the activity of PD-L1 B7-H1 and inhibited apoptosis of activated alloreactive 2C T cells. (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Goldberg, M.V., et. al. (2007). Blood. 110(1):186-92; Joshi, T., et. al. (2009). PLoS Pathog. 5(5):e1000431; Liu, X., et. al. (2016). Sci Rep. 6:36722). Flow Cytometry Analysis: A representative lot detected PD-L1 B7-H1 in Flow Cytometry applications (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Dong, H., et. al. (2004). Immunity. 20(3):327-36).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274
Immunogen: Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone: 10B5
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Inhibition Assays
Conjugate: Unconjugated
Host Species: Armenian Hamster
Research Discipline: Apoptosis & Cancer
Formulation: Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.
Gene Symbols: Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1
Isotype: __
Purification Method: Protein G purified
Molecular Weight of Antigen: __
Antigen:
PD-L1 B7-H1
Dilution:
Inhibits Activity/Function Analysis: A representative lot blocked the activity of PD-L1 B7-H1 and inhibited apoptosis of activated alloreactive 2C T cells. (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Goldberg, M.V., et. al. (2007). Blood. 110(1):186-92; Joshi, T., et. al. (2009). PLoS Pathog. 5(5):e1000431; Liu, X., et. al. (2016). Sci Rep. 6:36722). Flow Cytometry Analysis: A representative lot detected PD-L1 B7-H1 in Flow Cytometry applications (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Dong, H., et. al. (2004). Immunity. 20(3):327-36).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274
Immunogen:
Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone:
10B5
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Inhibition Assays
Conjugate:
Unconjugated
Host Species:
Armenian Hamster
Research Discipline:
Apoptosis & Cancer
Formulation:
Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.
Gene Symbols:
Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1
Isotype:
__
Purification Method:
Protein G purified
Molecular Weight of Antigen:
__
Antigen: ALK
Dilution: Western Blotting Analysis: A representative lot detected ALK in Western Blotting applications (Pulford, K., et. al. (2002). Br J Haematol. 116(1):135-41; Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunohistochemistry Analysis: A representative lot detected ALK in Immunohistochemistry applications (Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunofluorescence Analysis: A representative lot detected ALK in Immunofluorescence applications (Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunoprecipitation Analysis: A representative lot immunoprecipitated ALK in Immunoprecipitation applications (Pulford, K., et. al. (2002). Br J Haematol. 116(1):135-41; Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunohistochemistry (Paraffin) Analysis: A representative lot detected ALK in Immunohistochemistry applications (Pulford, K., et. al. (1997). Blood. 89(4):1394-404).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: ALK tyrosine kinase receptor;EC: 2.7.10.1;Anaplastic lymphoma kinase;CD246
Immunogen: His-tagged full length human recombinant ALK tyrosine kinase receptor.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: ALK1
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Signaling
Formulation: Purified mouse monoclonal antibody IgG3 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: ALK
Isotype: IgG3 κ
Purification Method: Protein G purified
Molecular Weight of Antigen: __
Antigen:
ALK
Dilution:
Western Blotting Analysis: A representative lot detected ALK in Western Blotting applications (Pulford, K., et. al. (2002). Br J Haematol. 116(1):135-41; Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunohistochemistry Analysis: A representative lot detected ALK in Immunohistochemistry applications (Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunofluorescence Analysis: A representative lot detected ALK in Immunofluorescence applications (Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunoprecipitation Analysis: A representative lot immunoprecipitated ALK in Immunoprecipitation applications (Pulford, K., et. al. (2002). Br J Haematol. 116(1):135-41; Pulford, K., et. al. (1997). Blood. 89(4):1394-404).Immunohistochemistry (Paraffin) Analysis: A representative lot detected ALK in Immunohistochemistry applications (Pulford, K., et. al. (1997). Blood. 89(4):1394-404).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
ALK tyrosine kinase receptor;EC: 2.7.10.1;Anaplastic lymphoma kinase;CD246
Immunogen:
His-tagged full length human recombinant ALK tyrosine kinase receptor.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
ALK1
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Signaling
Formulation:
Purified mouse monoclonal antibody IgG3 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
ALK
Isotype:
IgG3 κ
Purification Method:
Protein G purified
Molecular Weight of Antigen:
__