7188973
Phospho-RNA pol II CTD (Ser7) Monoclonal Antibody (3D4A12), Active Motif™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-RNA pol II CTD (Ser7)
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
220kDa; BOS_18773; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; EC 2.7.7.6; hRPB220; hsRPB1; MGC75453; Pol II S2p; POLR2; POLR2A; POLRA; Polymerase (RNA II (DNA directed), large polypeptide; polymerase (RNA) II (DNA directed) polypeptide A; polymerase (RNA) II (DNA directed) polypeptide A (220kD); polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; POLYMERASE II; RNA; RNA POL2; RNA polymerase II 1; RNA polymerase II subunit A; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1; RP02; Rpb1; RPB220; RPBh1; Rpii215; RpIILS; RPO2; RPO21; Rpo2-1; RPOL2; SUA8
Gene Symbols
POLR2A
Isotype
IgG2b
Purification Method
Protein G
Product Type
Antibody
Clone
3D4A12
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Human
Gene Accession No.
P24928
Gene ID (Entrez)
5430
Immunogen
This antibody was raised against a peptide containing the RNA pol II CTD sequence phosphorylated at serine 7.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
POLR2A
Related Products
Description
- DNA-directed RNA polymerase II subunit RPB1 (POLR1A) is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
- POLR1A is the largest subunit and is a catalytic component of RNA polymerase II which synthesizes mRNA precurors and many functional non-coding RNAs
- It also forms the polymerase active center together with the second largest subunit
- Pol II is the central component of the basal RNA polymerase II transcription machinery
- It is composed of mobile elements that move relative to each other
- RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft, and the jaws that are though to grab the incoming DNA template
- At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II
- A bridging helix emanates from RPB1 and crosses the cleft near the catalytic stie and is through to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition
- During transcription elongation, Pol II moves on the template as the transcript elongates
- Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II's largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination, and mRNA processing
- Regulation of gene expression levels depends on the balance between methylation and acetylation levelts of the CTD-lysines.
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Antigen: Phospho-RNA pol II CTD (Ser7)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: 220kDa; BOS_18773; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; EC 2.7.7.6; hRPB220; hsRPB1; MGC75453; Pol II S2p; POLR2; POLR2A; POLRA; Polymerase (RNA II (DNA directed), large polypeptide; polymerase (RNA) II (DNA directed) polypeptide A; polymerase (RNA) II (DNA directed) polypeptide A (220kD); polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; POLYMERASE II; RNA; RNA POL2; RNA polymerase II 1; RNA polymerase II subunit A; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1; RP02; Rpb1; RPB220; RPBh1; Rpii215; RpIILS; RPO2; RPO21; Rpo2-1; RPOL2; SUA8
Gene Symbols: POLR2A
Isotype: IgG2b
Purification Method: Protein G
Product Type: Antibody
Clone: 3D4A12
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Human
Gene Accession No.: P24928
Gene ID (Entrez): 5430
Immunogen: This antibody was raised against a peptide containing the RNA pol II CTD sequence phosphorylated at serine 7.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: POLR2A
Antigen:
Phospho-RNA pol II CTD (Ser7)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
220kDa; BOS_18773; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; EC 2.7.7.6; hRPB220; hsRPB1; MGC75453; Pol II S2p; POLR2; POLR2A; POLRA; Polymerase (RNA II (DNA directed), large polypeptide; polymerase (RNA) II (DNA directed) polypeptide A; polymerase (RNA) II (DNA directed) polypeptide A (220kD); polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; POLYMERASE II; RNA; RNA POL2; RNA polymerase II 1; RNA polymerase II subunit A; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1; RP02; Rpb1; RPB220; RPBh1; Rpii215; RpIILS; RPO2; RPO21; Rpo2-1; RPOL2; SUA8
Gene Symbols:
POLR2A
Isotype:
IgG2b
Purification Method:
Protein G
Product Type:
Antibody
Clone:
3D4A12
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Human
Gene Accession No.:
P24928
Gene ID (Entrez):
5430
Immunogen:
This antibody was raised against a peptide containing the RNA pol II CTD sequence phosphorylated at serine 7.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
POLR2A
Antigen: Histone H4R3me2a (asymmetric)
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: dimethyl H4; di-methyl H4; dimethyl Histone H4; di-methyl Histone H4; Di-Methyl-H4 Arg3; Di-Methyl-H4 R3; Di-Methyl-Histone H4 Arg3; Di-Methyl-Histone H4 R3; FO108; H4; H4 histone family, member A; H4 histone family, member I; H4 histone family, member J; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; H4 R3me2a; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4/p; H4-12; H4-16; H4-53; H4Arg3me2; H4Arg3me2a; H4Arg3me2s; H4c1; H4c11; H4c12; H4C13; H4c14; H4C15; H4C2; H4c3; H4C4; H4C5; H4C6; H4C8; H4c9; H4f16; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; H4R3; H4R3me2; H4R3me2s; HIST1H4; HIST1H4A; Hist1h4b; Hist1h4c; Hist1h4d; HIST1H4E; HIST1H4F; Hist1h4h; HIST1H4I; HIST1H4J; Hist1h4k; HIST1H4L; Hist1h4m; Hist2h4; Hist2h4a; HIST2H4B; HIST4H4; histone 1, H4a; histone 1, H4b; histone 1, H4e; histone 1, H4i; histone 2, H4; histone 2, H4a; Histone 4; Histone 4 family, member M; histone 4, H4; histone cluster 1, H4a; histone cluster 1, H4b; histone cluster 1, H4e; histone cluster 1, H4i; histone cluster 2, H4; histone cluster 2, H4a; Histone Cluster 4; histone cluster 4, H4; histone family member; Histone H4; Histone H4A; Histone H4R3; Histone H4R3me2; Histone H4R3me2a; histone IV, family 2; methyl Histone 3; methyl Histone H3; X04652
Gene Symbols: H4-16, H4C1, H4C14, H4C2, H4C5, H4C9
Isotype: IgG
Purification Method: Protein A
Product Type: Antibody
Clone: __
Applications: Dot Blot, ELISA, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P62805
Gene ID (Entrez): 121504, 8294, 8359, 8366, 8367, 8370
Immunogen: This Histone H4 dimethyl Arg3, asymmetric antibody was raised against a synthetic peptide containing dimethyl-Arg3 (asymmetric) of human histone H4.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: H4C1
Antigen:
Histone H4R3me2a (asymmetric)
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
dimethyl H4; di-methyl H4; dimethyl Histone H4; di-methyl Histone H4; Di-Methyl-H4 Arg3; Di-Methyl-H4 R3; Di-Methyl-Histone H4 Arg3; Di-Methyl-Histone H4 R3; FO108; H4; H4 histone family, member A; H4 histone family, member I; H4 histone family, member J; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; H4 R3me2a; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4/p; H4-12; H4-16; H4-53; H4Arg3me2; H4Arg3me2a; H4Arg3me2s; H4c1; H4c11; H4c12; H4C13; H4c14; H4C15; H4C2; H4c3; H4C4; H4C5; H4C6; H4C8; H4c9; H4f16; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; H4R3; H4R3me2; H4R3me2s; HIST1H4; HIST1H4A; Hist1h4b; Hist1h4c; Hist1h4d; HIST1H4E; HIST1H4F; Hist1h4h; HIST1H4I; HIST1H4J; Hist1h4k; HIST1H4L; Hist1h4m; Hist2h4; Hist2h4a; HIST2H4B; HIST4H4; histone 1, H4a; histone 1, H4b; histone 1, H4e; histone 1, H4i; histone 2, H4; histone 2, H4a; Histone 4; Histone 4 family, member M; histone 4, H4; histone cluster 1, H4a; histone cluster 1, H4b; histone cluster 1, H4e; histone cluster 1, H4i; histone cluster 2, H4; histone cluster 2, H4a; Histone Cluster 4; histone cluster 4, H4; histone family member; Histone H4; Histone H4A; Histone H4R3; Histone H4R3me2; Histone H4R3me2a; histone IV, family 2; methyl Histone 3; methyl Histone H3; X04652
Gene Symbols:
H4-16, H4C1, H4C14, H4C2, H4C5, H4C9
Isotype:
IgG
Purification Method:
Protein A
Product Type:
Antibody
Clone:
__
Applications:
Dot Blot, ELISA, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P62805
Gene ID (Entrez):
121504, 8294, 8359, 8366, 8367, 8370
Immunogen:
This Histone H4 dimethyl Arg3, asymmetric antibody was raised against a synthetic peptide containing dimethyl-Arg3 (asymmetric) of human histone H4.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
H4C1
Antigen: Histone H3K14me2
Concentration: Conc. Not Determined
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias: dimethyl H3; di-methyl H3; dimethyl histone H3; di-methyl histone H3; Di-Methyl-H3 K14; Di-Methyl-H3 Lys14; Di-Methyl-Histone H3 K14; Di-Methyl-Histone H3 Lys14; H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K14me2; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3.3A; H3.3B; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-143; H3-291; H3-3A; H3-3b; H3-53; H3-614; H3a; H3b; H3-B; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3f; H3-F; H3F1K; H3F2; H3F3; H3F3A; H3f3b; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3g; H3h; H3i; H3K14; H3Lys14me2; Hist1; Hist1h3a; HIST1H3B; Hist1h3c; Hist1h3d; HIST1H3E; Hist1h3f; HIST1H3G; Hist1h3h; HIST1H3I; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; histone 2, H3c2; histone 2, H3ca2; Histone 3; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; histone cluster 2, H3c2; histone cluster 2, H3c2, pseudogene; histone gene complex 1; histone H3; Histone H3.1; Histone H3.2; Histone H3.3; Histone H3.3C; Histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; Histone H3/m; Histone H3/o; Histone H3K14; Histone H3K14me2; histone variant H3.5; M32461; methyl Histone 3; methyl Histone H3; PP781
Gene Symbols: H3-3A, H3-3B, H3-5, H3C1, H3C10, H3C14, H3C15, H3C2, H3C7
Isotype: IgG
Purification Method: __
Product Type: Antibody
Clone: __
Applications: Dot Blot, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P68431, P84243, Q6NXT2, Q71DI3
Gene ID (Entrez): 126961, 3020, 3021, 333932, 440093, 8350, 8357, 8358, 8968
Immunogen: This Histone H3 dimethyl Lys14 antibody was raised against a peptide containing dimethyl-lysine 14 of human histone H3.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: H3-3A
Antigen:
Histone H3K14me2
Concentration:
Conc. Not Determined
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias:
dimethyl H3; di-methyl H3; dimethyl histone H3; di-methyl histone H3; Di-Methyl-H3 K14; Di-Methyl-H3 Lys14; Di-Methyl-Histone H3 K14; Di-Methyl-Histone H3 Lys14; H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K14me2; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3.3A; H3.3B; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-143; H3-291; H3-3A; H3-3b; H3-53; H3-614; H3a; H3b; H3-B; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3f; H3-F; H3F1K; H3F2; H3F3; H3F3A; H3f3b; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3g; H3h; H3i; H3K14; H3Lys14me2; Hist1; Hist1h3a; HIST1H3B; Hist1h3c; Hist1h3d; HIST1H3E; Hist1h3f; HIST1H3G; Hist1h3h; HIST1H3I; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; histone 2, H3c2; histone 2, H3ca2; Histone 3; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; histone cluster 2, H3c2; histone cluster 2, H3c2, pseudogene; histone gene complex 1; histone H3; Histone H3.1; Histone H3.2; Histone H3.3; Histone H3.3C; Histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; Histone H3/m; Histone H3/o; Histone H3K14; Histone H3K14me2; histone variant H3.5; M32461; methyl Histone 3; methyl Histone H3; PP781
Gene Symbols:
H3-3A, H3-3B, H3-5, H3C1, H3C10, H3C14, H3C15, H3C2, H3C7
Isotype:
IgG
Purification Method:
__
Product Type:
Antibody
Clone:
__
Applications:
Dot Blot, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P68431, P84243, Q6NXT2, Q71DI3
Gene ID (Entrez):
126961, 3020, 3021, 333932, 440093, 8350, 8357, 8358, 8968
Immunogen:
This Histone H3 dimethyl Lys14 antibody was raised against a peptide containing dimethyl-lysine 14 of human histone H3.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
H3-3A
Antigen: Cas9
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 200mM HEPES, 50mM sodium acetate with 100mM NaCl, 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: APAF3; APAF-3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; cas9; CASP 9; CASP9; CASP-9; caspase 9; caspase 9, apoptosis-related cysteine peptidase; Caspase9; Caspase-9; Caspase-9 precursor; Caspase-9 subunit p10; Caspase-9 subunit p35; CASPASE-9c; CRISPR-Cas9; CTD; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; OTTHUMP00000002324; PPP1R56; protein phosphatase 1, regulatory subunit 56; RNCASP9; RP11-265F14.3
Gene Symbols: CASP9
Isotype: IgG2a
Purification Method: Metal-chelate chromatography
Product Type: Antibody
Clone: __
Applications: ELISA, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Accession No.: P55211
Gene ID (Entrez): 842
Immunogen: This antibody was raised against a recombinant protein within the N-terminal region ofStreptococcus pyogeneCas9. This antibody recognizes Cas9 and dCas9.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: CASP9
Antigen:
Cas9
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
200mM HEPES, 50mM sodium acetate with 100mM NaCl, 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
APAF3; APAF-3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; cas9; CASP 9; CASP9; CASP-9; caspase 9; caspase 9, apoptosis-related cysteine peptidase; Caspase9; Caspase-9; Caspase-9 precursor; Caspase-9 subunit p10; Caspase-9 subunit p35; CASPASE-9c; CRISPR-Cas9; CTD; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; OTTHUMP00000002324; PPP1R56; protein phosphatase 1, regulatory subunit 56; RNCASP9; RP11-265F14.3
Gene Symbols:
CASP9
Isotype:
IgG2a
Purification Method:
Metal-chelate chromatography
Product Type:
Antibody
Clone:
__
Applications:
ELISA, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
P55211
Gene ID (Entrez):
842
Immunogen:
This antibody was raised against a recombinant protein within the N-terminal region ofStreptococcus pyogeneCas9. This antibody recognizes Cas9 and dCas9.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
CASP9