ABC495MI
MilliporeSigma™ anti-Caspase 3, Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABC495MI-Each-of-1 | In Stock | ₹ 48,852.19 |
ABC495MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,852.19
GST (18%): ₹ 8,793.394
Total Price: ₹ 57,645.584
Antigen
Caspase 3
Classification
Polyclonal
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
CASP3, CPP32
Immunogen
KLH-conjugated linear peptide corresponding to human Caspase 3 near the C-terminus.
Quantity
50 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_004337
Target Species
Human, Mouse
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Gene Accession No.
P42574
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with pro-caspase 3, the uncleaved/inactive caspase 3 (32kDa), and the p12 (12kDa), but not the p17 (17kDa) subunit of cleaved/active caspase 3.
Content And Storage
2°C to 8°C for one year
Related Products
Description
- Specifically detects Caspase 3 Clone: in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting Caspase-3 (EC 3.4.22.56; UniProt P42574; also known as Apopain, CASP-3, CPP-32, PARP cleavage protease, SCA-1, SREBP cleavage activity 1, Caspase 3 apoptosis-related cysteine protease, Cysteine protease CPP32, Procaspase3, Protein Yama) is encoded by the CASP3 (also known as CPP32, CPP32B) gene (Gene ID 836) in human
- Cysteine-aspartic proteases or Caspases play essential roles in apoptosis, necrosis, and inflammation
- Historically, caspases were numbered in the order in which they were identified
- Caspase-3 is initially produced with a propeptide sequence (a.a
- 1-9), the removal of which yields the 268 a.a
- caspase-3 proenzyme
- Upon activation, the proenzyme is proteolytically cleaved first between Asp175-Ser176 to generate a p20 (a.a
- 10-175) fragment and the p12 (a.a
- 176-277) subunit
- Further cleavage of the p20 fragment between Asp28-Ser29 produces the p17 (a.a
- 29-175) subunit
- The p17 and p12 dimerizes and forms the active caspase-3 enzyme
- Caspase-3 plays a central role in the sequential activation of caspases during the execution phase of cell apoptosis
- Caspase-3 mediates the proteolytic activation of caspases-6 and -7, while caspase-3 itself is processed and activated by caspase-8, -9, or -10
- Caspase-3 is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Compare Similar Items
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Antigen: Caspase 3
Classification: Polyclonal
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: CASP3, CPP32
Immunogen: KLH-conjugated linear peptide corresponding to human Caspase 3 near the C-terminus.
Quantity: 50 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_004337
Target Species: Human, Mouse
Applications: Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Gene Accession No.: P42574
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with pro-caspase 3, the uncleaved/inactive caspase 3 (32kDa), and the p12 (12kDa), but not the p17 (17kDa) subunit of cleaved/active caspase 3.
Content And Storage: 2°C to 8°C for one year
Antigen:
Caspase 3
Classification:
Polyclonal
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
CASP3, CPP32
Immunogen:
KLH-conjugated linear peptide corresponding to human Caspase 3 near the C-terminus.
Quantity:
50 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_004337
Target Species:
Human, Mouse
Applications:
Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Gene Accession No.:
P42574
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with pro-caspase 3, the uncleaved/inactive caspase 3 (32kDa), and the p12 (12kDa), but not the p17 (17kDa) subunit of cleaved/active caspase 3.
Content And Storage:
2°C to 8°C for one year
Antigen: BCL2A1/BFL-1
Classification: Polyclonal
Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols: BCL2A1; BCL2L5; BFL1; GRS; HBPA1
Immunogen: Recombinant protein corresponding to human BCL2A1/BFL-1.
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): NP_001108207
Target Species: Human
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: -20°C in undiluted aliquots for up to 12 months, Avoid Freeze/Thaw Cycles
Antigen:
BCL2A1/BFL-1
Classification:
Polyclonal
Formulation:
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols:
BCL2A1; BCL2L5; BFL1; GRS; HBPA1
Immunogen:
Recombinant protein corresponding to human BCL2A1/BFL-1.
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
NP_001108207
Target Species:
Human
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
-20°C in undiluted aliquots for up to 12 months, Avoid Freeze/Thaw Cycles
Antigen: EDG3
Classification: Polyclonal
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: S1PR3; EDG3
Immunogen: GST-tagged recombinant protein corresponding to the C-terminus of human EDG3.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_005217
Target Species: Human
Applications: Immunohistochemistry, Western Blot
Conjugate: __
Gene Accession No.: Q99500
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Antigen:
EDG3
Classification:
Polyclonal
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
S1PR3; EDG3
Immunogen:
GST-tagged recombinant protein corresponding to the C-terminus of human EDG3.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_005217
Target Species:
Human
Applications:
Immunohistochemistry, Western Blot
Conjugate:
__
Gene Accession No.:
Q99500
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Antigen: Cathepsin S
Classification: Polyclonal
Formulation: __
Gene Symbols: CTSS
Immunogen: KLH-conjugated linear peptide corresponding to 21 amino acids from the internal region of human cathepsin S.
Quantity: 100 μL
Research Discipline: Apoptosis and Cancer
Gene ID (Entrez): NP_004070.3.
Target Species: Human
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antibody detects cathepsin S in human cells. It targets an epitope within 21 amino acids from the internal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Cathepsin S
Classification:
Polyclonal
Formulation:
__
Gene Symbols:
CTSS
Immunogen:
KLH-conjugated linear peptide corresponding to 21 amino acids from the internal region of human cathepsin S.
Quantity:
100 μL
Research Discipline:
Apoptosis and Cancer
Gene ID (Entrez):
NP_004070.3.
Target Species:
Human
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antibody detects cathepsin S in human cells. It targets an epitope within 21 amino acids from the internal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.