ABE1858
MilliporeSigma™ Rabbit anti-Bora, Polyclonal,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1858-Each-of-1 | In Stock | ₹ 38,734.72 |
ABE1858 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Bora
Classification
Polyclonal
Gene Accession No.
Q6PGQ7
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Serum
Applications
Immunoprecipitation, Western Blot
Formulation
Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Symbols
BORA; C13orf34
Immunogen
GST-tagged recombinant human Bora N-terminal fragment.
Quantity
100 μL
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_079084
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
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Description
- Specifically detects Bora in Human samples, and it is validated for Immunoprecipitation, Western Blotting Protein aurora borealis (UniProt Q6PGQ7; also known as HsBora) is encoded by the BORA (also known as C13orf34) gene (Gene ID 79866) in human
- Originally identified as a co-factor for Aurora A-dependent asymmetrical cell divisions, Bora is an adaptor/scaffold protein that plays an important role in mitosis by mediating Aurora A-dependent Plk1 activation, and Bora depletion abolishes both Plk1 and Cdk1 activation
- Cellular Bora activity is negarively regulated by Plk1- and Cdk1-mediated phosphorylation
- Cdk1 initially phosphorylates Bora on S252, which primes Bora for Plk1-catalyzed S497 and T501 phosphorylation, leading to SCFβTrCP-mediated Bora ubiquitination and subsequent proteasomal degradation
- The negative feed-back regulation of Bora by the kinase it activates is important, as uncontrolled Bora overexpression perturbs Aurora A and Plk1 localization, leading to lengthened metaphase
- Similar to the counter regulation between Bora and Cdk1/Plk1 in somatic cells, Bora degradation is reported to be regulated via phosphorylation by Cdk1 and Plx1 in xenopus ooctyes
- Cdk1 is reported to phosphorylate Bora on Thr52, which blocks its degradation
- Fertilization induced calcium surge jump-starts the oscillations of the embryonic cycles by inducing Calcineurin-catalyzed Bora pThr52 dephosphorylation, leading to Bora degradation.
Compare Similar Items
Show Difference
Antigen: Bora
Classification: Polyclonal
Gene Accession No.: Q6PGQ7
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Serum
Applications: Immunoprecipitation, Western Blot
Formulation: Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Symbols: BORA; C13orf34
Immunogen: GST-tagged recombinant human Bora N-terminal fragment.
Quantity: 100 μL
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_079084
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Antigen:
Bora
Classification:
Polyclonal
Gene Accession No.:
Q6PGQ7
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Serum
Applications:
Immunoprecipitation, Western Blot
Formulation:
Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Symbols:
BORA; C13orf34
Immunogen:
GST-tagged recombinant human Bora N-terminal fragment.
Quantity:
100 μL
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_079084
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Antigen: __
Classification: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Applications: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Antigen:
__
Classification:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Applications:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Antigen: UTX (KDM6A)
Classification: Polyclonal
Gene Accession No.: O15550
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: __
Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: His-tagged recombinant fragment within the central region of human UTX (Seenundun, S., et al. (2010). EMBO J. 29(8):1401-1411).
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_066963
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Antigen:
UTX (KDM6A)
Classification:
Polyclonal
Gene Accession No.:
O15550
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
__
Applications:
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
His-tagged recombinant fragment within the central region of human UTX (Seenundun, S., et al. (2010). EMBO J. 29(8):1401-1411).
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_066963
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Antigen: AHCYL1 (IRBIT)
Classification: Polyclonal
Gene Accession No.: O43865
Host Species: Chicken
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: __
Applications: Western Blot
Formulation: Purified chicken polyclonal antibody in PBS with 0.02% Sodium azide.
Gene Symbols: AHCYL1, DCAL, XPVKONA
Immunogen: Recombinant protein corresponding to human AHCYL1(IRBIT).
Quantity: 100 μL
Research Discipline: Epigenetics, Nuclear Function
Gene ID (Entrez): NP_006612
Content And Storage: 2°C to 8°C for one year
Antigen:
AHCYL1 (IRBIT)
Classification:
Polyclonal
Gene Accession No.:
O43865
Host Species:
Chicken
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
__
Applications:
Western Blot
Formulation:
Purified chicken polyclonal antibody in PBS with 0.02% Sodium azide.
Gene Symbols:
AHCYL1, DCAL, XPVKONA
Immunogen:
Recombinant protein corresponding to human AHCYL1(IRBIT).
Quantity:
100 μL
Research Discipline:
Epigenetics, Nuclear Function
Gene ID (Entrez):
NP_006612
Content And Storage:
2°C to 8°C for one year