ABS148725UG
P2Y12 Receptor, Rabbit anti-Rat, Human, Polyclonal, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS148725UG-Each-of-1 | In Stock | ₹ 16,456.61 |
ABS148725UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
P2Y12 Receptor
Classification
Polyclonal
Dilution
Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Gene Alias
P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Host Species
Rabbit
Molecular Weight of Antigen
∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
25 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_073625
Target Species
Rat, Human
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
P2RY12;HORK3
Immunogen
KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Related Products
Description
- Anti-P2Y12 Receptor, Cat
- No
- ABS1487, is a rabbit polyclonal antibody that detects P2Y purinoceptor 12 and has been tested for Immunohistochemistry (Paraffin) and Western Blotting
- P2Y purinoceptor 12 (UniProt: Q9H244; also known as P2Y12, ADP-glucose receptor, ADPG-R, P2T(AC), P2Y(AC), P2Y(cyc), P2Y12 platelet ADP receptor, P2Y(ADP), SP1999) is encoded by the P2RY12 (also known as HORK3) gene (Gene ID: 64805) in human
- P2Y12 is a multi-pass metabotropic receptor that is highly expressed in the platelets
- Lower expression levels have been observed in the brain, lung, and adrenal glands
- P2Y12 serves as a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system
- It is not activated by UDP and UTP
- It is required for normal platelet aggregation and blood coagulation
- It is the predominant receptor involved in the ADP-stimulated activation of the glycoprotein IIb/IIIa receptor
- Activation of the glycoprotein IIb/IIIa receptor results in enhanced platelet degranulation and thromboxane production, and prolonged platelet aggregation
- P2Y12 receptor has also been reported to be expressed on microglia and is required to neuropathic pain following peripheral nerve injury
- P2Y12 has seven transmembrane, four cytoplasmic, and four extracellular domains
- The transmembrane helices are somewhat tilted and/or kinked
- Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices
- Mutations in P2RY12 gene have been linked to bleeding disorders resulting from severe impairment of platelet response to ADP resulting in defective platelet aggregation
- (Ref.: Burnstock G
- (2009)
- Curr
- Pharm
- Des
- 15(15);1717-35; Damman, P., et al
- (2012)
- J
- Thromb
- Thrombolysis
- 33(2); 143-153).
Compare Similar Items
Show Difference
Antigen: P2Y12 Receptor
Classification: Polyclonal
Dilution: Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Gene Alias: P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Host Species: Rabbit
Molecular Weight of Antigen: ∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_073625
Target Species: Rat, Human
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: P2RY12;HORK3
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
P2Y12 Receptor
Classification:
Polyclonal
Dilution:
Immunohistochemistry (Paraffin) Analysis: A 1:250-1,000 dilution from a representative lot detected P2Y12 Receptor in human cerebral cortex and human tonsil tissue sections.Western Blotting Analysis: 1μg/mL from a representative lot detected P2Y12 Receptor in human platelet cell lysate.
Gene Alias:
P2Y purinoceptor 12;ADP-glucose receptor;ADPG-R;P2T(AC);P2Y(AC);P2Y(cyc);P2Y12 platelet ADP receptor;P2Y(ADP);SP1999
Host Species:
Rabbit
Molecular Weight of Antigen:
∽50 kDa observed; 39.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_073625
Target Species:
Rat, Human
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
P2RY12;HORK3
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the internal region of human P2Y purinoreceptor 12.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detects P2Y12 receptor. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: Frizzled-2
Classification: Polyclonal
Dilution: __
Gene Alias: Fz-2;hFz2;FzE2
Host Species: Rabbit
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human
Applications: Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: FZD2
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Frizzled-2
Classification:
Polyclonal
Dilution:
__
Gene Alias:
Fz-2;hFz2;FzE2
Host Species:
Rabbit
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
FZD2
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: Frizzled-2
Classification: Polyclonal
Dilution: __
Gene Alias: Fz-2;hFz2;FzE2
Host Species: Rabbit
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 25 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human
Applications: Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: FZD2
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Frizzled-2
Classification:
Polyclonal
Dilution:
__
Gene Alias:
Fz-2;hFz2;FzE2
Host Species:
Rabbit
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
25 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
FZD2
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: SCYL1
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001041683.1
Target Species: Human, Mouse
Applications: Western Blot, Immunocytochemistry
Conjugate: Unconjugated
Formulation: __
Gene Symbols: SCYL1,CVAK90,GKLP,NTKL,TAPK,TEIF,TRAP,HT01
Immunogen: KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
SCYL1
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001041683.1
Target Species:
Human, Mouse
Applications:
Western Blot, Immunocytochemistry
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
SCYL1,CVAK90,GKLP,NTKL,TAPK,TEIF,TRAP,HT01
Immunogen:
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.