CD184 Mouse anti-Human, PE-CF594, Clone: 12G5, BD

Description

• The 12G5 monoclonal antibody specifically binds to CD184, also known as CXCR4 and Fusin
• CD184/CXCR4 is a seven-transmembrane domain, G-protein-linked, glycoprotein chemokine receptor
• CD184 serves as a receptor for the C-X-C chemokine, SDF-1
• It is expressed on a wide variety of hematopietic cells, vascular endothelial cells and cells of the nervous system
• CD184 plays a variety of roles in hematopoiesis, vascularization and neural development
• CD184 also functions as a coreceptor for infection with T-cell tropic strains of HIV-1 and as a receptor for CD4-independent infection by some HIV isolates
• The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T-cell tropic isolates of HIV-1
• This antibody is conjugated to BD Horizon™ PE-CF594, which has been developed exclusively by BD Biosciences as a better alternative to PE-Texas Red™
• PE-CF594 excites and emits at similar wavelengths to PE-Texas Red™ yet exhibits improved brightness and spectral characteristics
• Due to PE having maximal absorption peaks at 496nm and 564nm, PE-CF594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as PE-Texas Red™ (eg 610/20-nm filter).