CD19 Mouse anti-Human, BB515, Clone: HIB19, BD

Description

• The HIB19 monoclonal antibody specifically binds to the 95 kDa type I transmembrane CD19 glycoprotein
• CD19 is expressed during all stages of B-cell maturation and differentiation, except on plasma cells
• CD19 is also present on follicular dendritic cells
• It is not found on T cells or on normal granulocytes
• CD19 is a signal transduction molecule that regulates B cell development, activation, proliferation and differentiation
• It associates with the complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells
• Anti-CD19 clone HIB19 partially blocks the binding of clone B43, another CD19-specific monoclonal antibody
• The antibody was conjugated to BD Horizon™ BB515 which was developed exclusively by BD Biosciences
• With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g., 530/30-nm filter)
• This dye provides a much brighter alternative to FITC with less spillover into the PE detector.