Rac1 Mouse, Unlabeled, Clone: 102, BD

Description

• Rac1 is a member of the expanding family of Ras-related GTPase proteins
• These small proteins have the ability to switch between two different conformational states: the active (GTP-bound) and the inactive (GDP-bound)
• The GTPase activity is increased by specific activator proteins named GAPs
• Rac1, like many of its relatives, contains the consensus sequence Cys-X-X-X-COOH, which localizes it to the plasma membrane
• Growth factor stimulation of cells results in a dramatic reorganization of the actin filament network and membrane ruffling, processes for which Rac1 is essential
• Constitutive expression of Rac1 leads to cell transformation
• This process is mediated by the Rac1-dependent activation of the p65PAK serine/threonine kinase
• In addition, IQGAP1 has been identified as a GTPase activating protein specific for Rac1
• Due to sequence homology among various small GTPase family members, potential cross-reactivity could be observed with this antibody
• BD Biosciences Pharmingen, however, has not performed such cross-reactivity testing
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.