AKAP149 Mouse, Unlabeled, Clone: 6, BD

Description

• The targeting of protein kinases and phosphatases to cellular compartments in a timely manner may provide specificity in signal transduction events
• For instance, attachment of type II cAMP-dependent Protein Kinase (PKA) to the cytoskeleton occurs through the binding of the regulatory subunit (RII) to microtubule associated-protein 2
• Several proteins, such as microtubule-associated protein 2, have been identified as PKA type I/II anchoring proteins and form a family named AKAP ( A - K inase A nchor P roteins)
• AKAP149 is a protein of 903 amino acids
• It has a PKA [RII] binding site at amino acids 355-376 preceded by a leucine zipper domain
• AKAP149 mRNA has been reported to be expressed ubiquitously, with the highest levels in prostate and small intestine
• AKAP149 contains a KH domain characteristic of RNA-binding proteins
• Thus, AKAP149 is a PKA [RII] anchoring protein that may target this kinase to sites of RNA processing for regulation of RNA binding protein activity
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.